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Phase division and transition modeling based on the dominant phase identification for multiphase batch process quality prediction

机译:基于多相批处理质量预测主导阶段识别的相位划分和转换建模

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摘要

Batch processes are carried out from one steady phase to another one, which may have multiphase and transitions. Modeling in transitions besides in the steady phases should also be taken into consideration for quality prediction. In this paper, a quality prediction strategy is proposed for multiphase batch processes. First, a new repeatability factor is introduced to divide batch process into different steady phases and transitions. Then, the different local cumulative models that considered the cumulative effect of process variables on quality are established for steady phases and transitions. Compared with the reported modeling methods in transitions, a novel just-in-time model can be established based on the dominant phase identification. The proposed method can not only consider the dynamic characteristic in the transition but also improve the accuracy and the efficiency of transitional models. Finally, online quality prediction is performed by accumulating the prediction results from different phases and transitions. The effectiveness of the proposed method is demonstrated by penicillin fermentation process.
机译:将批处理从一个稳定阶段进行到另一个稳定阶段,这可能具有多相和转变。还应考虑到稳定阶段的过渡的建模,以考虑质量预测。本文提出了一种用于多相批处理方法的质量预测策略。首先,引入了一种新的可重复性因子以将批处理分为不同的稳态和转换。然后,为稳定阶段和过渡建立了考虑过程变量累积效应的不同局部累积模型。与报告的转换中的建模方法相比,可以基于显性阶段识别来建立新的即时模型。该方法不仅可以考虑转型中的动态特性,而且还可以提高过渡模型的准确性和效率。最后,通过累积来自不同阶段和转换的预测结果来执行在线质量预测。通过青霉素发酵过程证明了所提出的方法的有效性。

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