Estimation of Unbound Carboplatin Clearance From Total Plasma Concentrations as a Means of Facilitating Therapeutic Drug Monitoring

Moeung Sotheara; Chevreau Christine; Poinsignon Vianney; Guitton Jerome; Lelievre Benedicte; Ciccolini Joseph; Gladieff Laurence; Massart Christophe; Flechon Aude; Delva Remy; Gravis Gwenaelle; Lotz Jean-Pierre; Bay Jacques-Olivier; Gross-Goupil Marine; Delahousse Julia; Filleron Thomas; Lochon Isabelle; Chatelut Etienne; Thomas Fabienne

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Estimation of Unbound Carboplatin Clearance From Total Plasma Concentrations as a Means of Facilitating Therapeutic Drug Monitoring

机译：从总血浆浓度的估算估算总血浆浓度作为促进治疗药物监测的方法

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Background: Therapeutic drug monitoring of carboplatin is based on its unbound clearance (CLU) determined by Bayesian analysis on unbound (U) concentrations. However, the ultrafiltration of plasma samples presents technical and time constraints. Therefore, this study aims to estimate CLU using total plasma (P) concentrations.

机译：背景技术：Carboplatin的治疗药物监测基于其由贝叶斯分析对未结合（U）浓度确定的未结合清除（CLU）。然而，等离子体样本的超滤具有技术和时间限制。因此，本研究旨在使用总血浆（P）浓度来估计CLU。

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来源
《Therapeutic Drug Monitoring》 |2019年第1期|共9页
作者
Moeung Sotheara; Chevreau Christine; Poinsignon Vianney; Guitton Jerome; Lelievre Benedicte; Ciccolini Joseph; Gladieff Laurence; Massart Christophe; Flechon Aude; Delva Remy; Gravis Gwenaelle; Lotz Jean-Pierre; Bay Jacques-Olivier; Gross-Goupil Marine; Delahousse Julia; Filleron Thomas; Lochon Isabelle; Chatelut Etienne; Thomas Fabienne;
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作者单位

IUCT Oncopole Inst Claudius Regaud Toulouse France;

IUCT Oncopole Inst Claudius Regaud Toulouse France;

Univ Paris Saclay Inst Gustave Roussy Pharmacol Dept Villejuif France;

CHU Lyon Lab Pharmacol &

Toxicol Lyon France;

CHU Angers Lab Pharmacol &

Toxicol Angers France;

CHU La Timone Marseille France;

IUCT Oncopole Inst Claudius Regaud Toulouse France;

Inst Gustave Roussy Med Oncol Dept Villejuif France;

Ctr Leon Berard Lyon France;

Inst Cancerol Ouest Paul Papin Angers France;

Inst Paoli Calmettes Marseille France;

Tenon Hosp Paris France;

CHU Clermont Ferrand Clermont Ferrand France;

Hop St Andre Bordeaux France;

CHU Lyon Lab Pharmacol &

Toxicol Lyon France;

IUCT Oncopole Inst Claudius Regaud Toulouse France;

IUCT Oncopole Inst Claudius Regaud Toulouse France;

IUCT Oncopole Inst Claudius Regaud Toulouse France;

IUCT Oncopole Inst Claudius Regaud Toulouse France;

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原文格式 PDF
正文语种 eng
中图分类生药学（天然药物学）;
关键词
unbound carboplatin; therapeutic drug monitoring; high-dose chemotherapy; estimation; total plasma carboplatin concentration;

机译：未结合的卡铂;治疗药物监测;高剂量化疗;估计;总血浆卡铂浓度;

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专利

1. Estimation of Unbound Carboplatin Clearance From Total Plasma Concentrations as a Means of Facilitating Therapeutic Drug Monitoring [J] . Moeung Sotheara, Chevreau Christine, Poinsignon Vianney, Therapeutic Drug Monitoring . 2019,第1期

机译：从总血浆浓度的估算估算总血浆浓度作为促进治疗药物监测的方法
2. Variability in Trough Total and Unbound Teicoplanin Concentrations and Achievement of Therapeutic Drug Monitoring Targets in Adult Patients with Hematological Malignancy [J] . Byrne Catherine J., Roberts Jason A., McWhinney Brett, Antimicrobial agents and chemotherapy. . 2017,第6期

机译：芽总和未结合的Teicoplanin浓度的变异性和成年血液恶性肿瘤患者治疗药物监测靶标的变异性
3. Therapeutic drug monitoring of beta-lactam antibiotics in the critically ill: direct measurement of unbound drug concentrations to achieve appropriate drug exposures [J] . Wong Gloria, Briscoe Scott, McWhinney Brett, The Journal of Antimicrobial Chemotherapy . 2018,第11期

机译：β-内酰胺抗生素的治疗药物监测在批判性病中：直接测量未结合的药物浓度，以达到适当的药物曝光
4. EFFICIENT PHOSPHOLIPIDS REMOVING CLEAN-UP SPE-LC-MS/MS METHOD FOR SIMULTANEOUS PLASMA QUANTIFICATION OF 11 TYROSINE KINASE INHIBITORS AND CAFFEINE. APPLICATION TO THERAPEUTIC DRUG MONITORING [C] . Dora Koller, Viktoryia Vaitsekhovich, Cecile Mba, International Mass Spectrometry Conference . 2018

机译：高效磷脂去除清洁SPE-LC-MS / MS法，用于同时血浆定量11酪氨酸激酶抑制剂和咖啡因。应用于治疗药物监测
5. Simultaneous Determination of Free Concentration, Total Concentration, and Plasma Binding Capacity of Bioactive Compounds [D] . Cibotaru, Dorina. 2020

机译：同时测定生物活性化合物的自由浓度，总浓度和血浆结合能力
6. Variability in Trough Total and Unbound Teicoplanin Concentrations and Achievement of Therapeutic Drug Monitoring Targets in Adult Patients with Hematological Malignancy [O] . Catherine J. Byrne, Jason A. Roberts, Brett McWhinney, 2017

机译：成年血液恶性肿瘤患者低谷总和未结合替考拉宁浓度的变异性和治疗药物监测目标的实现
7. Variability in trough total and unbound teicoplanin concentrations and achievement of therapeutic drug monitoring targets in adult patients with hematological malignancy [O] . Byrne, Catherine J., Roberts, Jason A., McWhinney, Brett, 2017

机译：成年血液恶性肿瘤患者谷中总和未结合替考拉宁浓度的变化和治疗药物监测目标的实现

Estimation of Unbound Carboplatin Clearance From Total Plasma Concentrations as a Means of Facilitating Therapeutic Drug Monitoring

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