The Role of beta-Catenin in Bcr/Abl Negative Myeloproliferative Neoplasms: An Immunohistochemical Study

摘要

The dysregulation of the Wnt/beta-catenin signaling pathway causes various diseases. In this study we aimed to reveal the role of beta-catenin in bcr/abl-negative myeloproliferative neoplasms. The expression of beta-catenin was examined in bone marrow with immunohistochemical method in 66 patients and in 30 control participants. The results suggest that beta-catenin has a role in the angiogenesis of primary myelofibrosis and in the thrombopoiesis of policythemia vera and essential thrombocytemia.