Platelet indices in preterm premature rupture of membranes and their relation with adverse neonatal outcomes

摘要

Abstract Aim Preterm premature rupture of membranes (PPROM) is not only the most common distinguishable cause of preterm delivery, but is also associated with adverse neonatal outcomes. We determined the platelet indices in PPROM cases and evaluated their relationship to adverse neonatal outcomes. Methods Fifty patients with PPROM and 50 patients who experienced spontaneous preterm labor at 37 gestational weeks were evaluated. Complete blood counts, birth weights, Apgar scores, presence of sepsis and respiratory distress syndrome (RDS) and neonatal intensive care unit admission were recorded. Results Patients with PPROM had increased mean platelet volumes (9.40 vs 10; P =?0.01), plateletcrit (0.19 vs 0.21; P =?0.03) and a higher frequency of neonatal sepsis (18% vs 38%; P =?0.02). Platelet indices in the patient group were compared according to the development of RDS. Plateletcrit values were higher in the RDS positive group (0.23?±?0.05 vs. 0.21?±?0.04; P =?0.04). The cut‐off value for plateletcrit was determined as 0.22, and the probability of RDS increased 5.86 times when plateletcrit values exceeded 0.22 (odds ratio 5.86, 95% confidence interval?1.01–32.01; P ?=?0.04). A one‐unit increase in platelet distribution width resulted in a 1.33‐fold increase in the risk of RDS (odds ratio 1.33, 95% confidence interval?1.01–1.77; P =?0.04). Conclusion Mean platelet volumes and plateletcrit significantly increased and plateletcrit had a predictive value for RDS in PPROM cases. Monitoring plateletcrit may be promising for predicting the development of RDS, one of the most common and serious complications of PPROM rupture.