Comparison of Vancomycin Treatment Failures for Methicillin-Resistant Staphylococcus aureus Bacteremia Stratified by Minimum Inhibitory Concentration

摘要

Background: Optimal treatment of methicillin-resistant Staphylococcus aureus bacteremias (MRSABs) with vancomycin minimum inhibitory concentrations (MICs) high within the susceptible range is of concern due to the high rate of mortality and increased prevalence. Objective: The purpose of this study is to evaluate vancomycin treatment failures in patients with MRSAB stratified by vancomycin MIC. Methods: In this retrospective chart review, patients >=19 years of age with MRSAB between July 2010 and December 2016 were included if they received intravenous vancomycin for >72 hours. Vancomycin treatment failures were compared between patients with vancomycin MICs of <=1 mg/L and 2 mg/L. Vancomycin treatment failure was defined as microbiological failure at 7 days.