A Study to Compare the Effect of Adding-12 Days DEC Regimen to 6 Years Annual Mass Drug Administration to Eliminate Microfilaraemia Infection in The Community in Rural Kanpur, Uttar Pradesh, India

摘要

Lymphatic filariasis is a major public health problem of tropical countries. Although its elimination is planned as global effort using mass drug administration in affected communities but its impact has been influenced by MDA coverage across countries. The drug coverage is affected by fever as side effect and its continuation for over 6 years which affect the population participation. Therefore alternative approaches are needed which can show impact faster than standard MDA. Present research using additional 12 days dose of DEC to mf carriers, show that if drug coverage could be regular, sustainable impact could be created in 4 years. Lymphatic Filariasis (LF) is a deforming and disabling infectious disease that causes elephantiasis and Hydroceles. The infection affects some 120 million people in an estimated 83 countries in tropical and subtropical regions, with an estimated 1.2 billion individuals at risk. Most LF is caused by W. bancrofti parasite. The World Health Assembly passed a resolution in 1997 that called global elimination of LF as a public health problem (WHA Resolution 50.29, see wwwiilariasis.org). The World Health Organization (WHO) thereafter developed a plan for elimination that is based on selective diagnosis to identify endemic areas followed by repeated, annual cycles of mass drug administration (MDA) of antifilarial medications. WHO reported that approximately 1.9 billion doses of MDA were distributed to more than 500 million individuals between 2000 and 2007.MThus, the Global Programme to Eliminate Lymphatic Filariasis (GPELF) is the largest infectious disease intervention program attempted to date based on MDA.