Comparison of change in body weight between contraception containing 30-mu g ethinylestradiol/2-mg chlormadinone acetate or 30-mu g ethinylestradiol/3-mg drospirenone: a randomised controlled trial

摘要

Objectives: The aim of this study was to compare changes in body weight in women using a combined oral contraceptive (COC) consisting of 30-mu g ethinylestradiol (EE) and 2-mg chlormadinone acetate (CMA) or a COC consisting of 30-mu g EE and 3-mg drospirenone (DRSP). Methods: This randomised double-blind controlled trial (ClinicalTrials.gov NCT01608698) was conducted at a university hospital-based clinic in Thailand between June 2012 and September 2015. A total of 102 women were enrolled in the study, 99 of whom were randomised to EE/CMA (n = 45) or EE/DRSP (n = 54). Each participant was treated for six cycles. Body weight and other parameters as well as side effects were recorded at baseline and at the end of the third and sixth cycles of treatment. Results: A significant difference was observed in mean body weight change between the EE/CMA and EE/DRSP groups from both baseline to third cycle (0.51 +/- 1.36 kg vs -0.43 +/- 1.56 kg; p = .003) and baseline to sixth cycle (1.00 +/- 1.84 kg vs -0.20 +/- 2.23 kg; p = .013). The mean difference in body mass index and waist circumference had a similar trend to that of the mean difference in body weight. There was no significant difference in side effects between groups. Conclusion: A COC containing 30-mu g EE/3-mg DRSP tended to confer a significantly more favourable change in body weight over a 6-month period compared with a COC containing 30-mu g EE/2-mg CMA, which was associated with an increase in body weight.