Overdiagnosis and overtreatment associated with breast cancer mammography screening: A simulation study with calibration to population-based data

摘要

Objectives: The magnitude of overdiagnosis of breast cancer associated with mammography screening remains controversial because of methodological issues. The objective of this study was to quantify overdiagnosis and overtreatment associated with a population-based screening programme, taking into account lead time and uncertainty concerning baseline incidence of breast cancers.