Differentiating New from Newly Detected: Melioidosis in Yap, Federated States of Micronesia

摘要

Abstract. Melioidosis is a bacterial infection caused by exposure to water or soil that contains Burkholderia pseu- domallei {Bp). Burkholderia pseudomallei is endemic to many tropical and subtropical areas of the world. In 2013, the first case of melioidosis was recognized in Yap, the Federated States of Micronesia. Six additional cases were identified in the subsequent 3 years. An investigation was initiated to understand the epidemiology of melioidosis in Yap. Serum from family and community members of the identified cases were tested for antibodies to Bp. Archived serum from a 2007 Zika serosurvey were also tested for antibodies to Bp. Sequencing of bacterial isolates was performed to understand bacterial