Effects of leptin and ghrelin on neural cue-reactivity in alcohol addiction: Two streams merge to one river?

摘要

Leptin and ghrelin and a "cross-talk" between both hormones were implicated in the pathophysiology of alcohol dependence, both modulating alcohol craving and drug-seeking. To date, the neurobiological mechanisms underlying those effects are still little-known. We thus investigated the effect of leptin and ghrelin on alcohol cue induced brain response, alcohol craving and relapse risk in alcohol-dependent subjects.