Lower cancer-specific distress and inflammatory cytokine levels after a stress management intervention predict lower fatigue interference into survivorship in non-metastatic breast cancer patients

摘要

Background. Prior work has shown that Cognitive Behavioral Stress Management (CBSM) decreases cancer-related intrusive thoughts and inflammatory gene signaling over the initial 12 months of primary breast cancer (BCa) treatment, though women revealed individual variation in these changes. Little is known if such psychobiological changes predict longer-term symptom management, including fatigue. We tested whether 6-month post-intervention levels of cancer-related intrusive thoughts predicted fatigue at 18 months and whether levels of inflammatory markers between these two points (12 months) mediated this relationship within the CBSM condition. Methods.