Alzheimer's Disease Current Treatments and Potential New Agents

摘要

Alzheimer's disease (AD) is becoming more prevalent worldwide. Four medications (donepezil, rivastigmine, galantamine, and memantine) are approved to treat AD symptoms. Despite extensive research over the past hundred years, little is known about what causes AD or how to effectively treat it. However, progress is being made in elucidating the complex pathophysiology that leads to the development of plaques and tangles, two predominant contributing factors in AD. This knowledge has fueled research aimed at developing disease-modifying agents to halt disease progression. Current research focuses on agents that target secretase enzymes to prevent plaque accumulation. Although the research appears promising, these agents have produced few successful results.The pharmacist can ensure that patients take their AD medications properly, communicate with patients and caregivers about treatment expectations, and inform them about emerging therapies.