Standardized Seed Extract of Quisqualis indica (HU-033) Attenuates Testosterone Propionate-Induced Benign Prostatic Hyperplasia raa1-Adrenergic Receptors and Androgen/Estrogen Signaling

摘要

Benign prostatic hyperplasia (BPH) is an age-related disease characterized by prostatic enlargement and is the most common urologic symptoms in elderly men 60 years of age and older. Previously, we documented that 70% eth-anol (EtOH) seed extract of Quisqualis indica (Q.I) attenuates pathological condition of testosterone propionate (TP)-induced BPH rat model via modulation of proliferation and apoptosis of prostate cells. Based on this potential of QI, we pro-duced standardized seed extract of QI (HU-033) in order to prove further mechanisms. In this study, we aimed to suggest forther mechanisms underlying the relationship between BPH and HU-033. Through not only cellular and nuclear recep-tor functional assays, but TP-mediated BPH rat model treated with HU-033, we demonstrated that HU-033 exerted antagonist effect on alpha1_A- and alpha1_D-adrenergic receptors in vitro and inhibitory effect on protein expression of androgen receptor and estrogen receptor alpha in vivo. Taken together, these results suggest that HU-033 is a novel candidate for the management of BPH.