Understanding the process-product-performance interplay of spray dried drug-polymer systems through complete structural and chemical characterization of single spray dried particles

Poozesh Sadegh; Setiawan Nico; Arce Freddy; Sundararajan Pavithra; Della Rocca Joseph; Rumondor Alfred; Wei Douglas; Wenslow Robert; Xi Hanmi; Zhang Shawn; Stellabott Joyce; Su Yongchao; Moser Justin; Marsac Patrick Jules

首页> 外文期刊>Powder Technology: An International Journal on the Science and Technology of Wet and Dry Particulate Systems >Understanding the process-product-performance interplay of spray dried drug-polymer systems through complete structural and chemical characterization of single spray dried particles

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Understanding the process-product-performance interplay of spray dried drug-polymer systems through complete structural and chemical characterization of single spray dried particles

机译：通过单喷雾干燥颗粒的完全结构和化学表征，了解喷雾干燥药物 - 聚合物系统的过程 - 产品性能相互作用

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摘要

A complete description of the particle formation process can only be realized with techniques that enable the measurement of the composition and structural dependence of individual particles.

机译：颗粒形成过程的完整描述只能通过能够测量组成和各个颗粒的结构依赖性的技术实现。

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来源
《Powder Technology: An International Journal on the Science and Technology of Wet and Dry Particulate Systems》 |2017年第2017期|共11页
作者
Poozesh Sadegh; Setiawan Nico; Arce Freddy; Sundararajan Pavithra; Della Rocca Joseph; Rumondor Alfred; Wei Douglas; Wenslow Robert; Xi Hanmi; Zhang Shawn; Stellabott Joyce; Su Yongchao; Moser Justin; Marsac Patrick Jules;
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作者单位

Univ Kentucky Coll Pharm Lexington KY 40536 USA;

Univ Kentucky Coll Pharm Lexington KY 40536 USA;

Univ Kentucky Coll Pharm Lexington KY 40536 USA;

Merck Res Labs West Point PA 19486 USA;

Merck Res Labs West Point PA 19486 USA;

Merck Res Labs West Point PA 19486 USA;

Carl Zeiss Microscopy One Zeiss Dr Thornwood NY 10594 USA;

Crystal Pharmatech 675 US Highway One North Brunswick NJ 08902 USA;

Merck Res Labs West Point PA 19486 USA;

DigiM Solut LLC 67 S Bedford St Suite 400 West Burlington MA 01803 USA;

Merck Res Labs West Point PA 19486 USA;

Merck Res Labs West Point PA 19486 USA;

Merck Res Labs West Point PA 19486 USA;

Univ Kentucky Coll Pharm Lexington KY 40536 USA;

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原文格式 PDF
正文语种 eng
中图分类粉末技术;化学工业;
关键词
Amorphous solid dispersion; Spray drying; Particle sizing; Image analysis; Microparticles; Droplet drying kinetics; Mass transfer; Droplet theory; Spray technology; High resolution imaging; Focused ion beam scanning electron microscopy; Energy dispersive X-ray analysis;

机译：无定形固体分散;喷雾干燥;颗粒尺寸;图像分析;微粒;液滴干燥动力学;传质;液滴理论;喷涂技术;高分辨率成像;聚焦离子束扫描电子显微镜;能量分散X射线分析;

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专利

1. Understanding the process-product-performance interplay of spray dried drug-polymer systems through complete structural and chemical characterization of single spray dried particles [J] . Poozesh Sadegh, Setiawan Nico, Arce Freddy, Powder Technology: An International Journal on the Science and Technology of Wet and Dry Particulate Systems . 2017,第期

机译：通过单喷雾干燥颗粒的完全结构和化学表征，了解喷雾干燥药物 - 聚合物系统的过程 - 产品性能相互作用
2. A physical and chemical comparison of material from a conventional spray-dried system and a single particle spray-dried system [J] . WhitesideP.T., ZhangJ., ParkerA.P., International Journal of Pharmaceutics . 2013,第1a2期

机译：来自常规喷雾干燥系统和单颗粒喷雾干燥系统的材料的物理和化学比较
3. Advanced spray-dried design, physicochemical characterization, and aerosol dispersion performance of vancomycin and clarithromycin multifunctional controlled release particles for targeted respiratory delivery as dry powder inhalation aerosols [J] . ParkC.-W., LiX., VogtF.G., International Journal of Pharmaceutics . 2013,第1a2期

机译：万古霉素和克拉霉素多功能控释颗粒的先进喷雾干燥设计，理化特性和气溶胶分散性能，可作为干粉吸入气雾剂靶向呼吸道
4. From Droplet to Particle: Evolving 3-D structural and chemical properties of a spray dried particle [C] . Justin Moser, Pavol Rajniak, Patrick Marsac, AIChE Meeting . 2015

机译：从液滴到颗粒：演化喷雾干燥颗粒的3-D结构和化学性质
5. A study of the physical and chemical stability of spray dried aluminum hydroxycarbonate and of drying methods for aluminum hydroxycarbonate gel: Part I. The physical and chemical stability of spray dried aluminum hydroxycarbonate gel. Part II. Drying methods for aluminum hydroxycarbonate gel. [D] . Hancock, Kim Elaine. 1994

机译：喷雾干燥的羟基碳酸铝的物理和化学稳定性及其干燥方法的研究：第一部分。喷雾干燥的羟基碳酸铝的物理和化学稳定性。第二部分羟基碳酸铝凝胶的干燥方法。
6. Physicochemical characterization and aerosol dispersion performance of organic solution advanced spray-dried cyclosporine A multifunctional particles for dry powder inhalation aerosol delivery [O] . Xiao Wu, Weifen Zhang, Don Hayes Jr, 2013

机译：有机溶液的物理化学特征和气溶胶分散性能先进的喷雾干燥环孢霉素A用于干粉吸入气雾剂输送的多功能颗粒
7. Physicochemical characterization and aerosol dispersion performance of organic solution advanced spray-dried cyclosporine A multifunctional particles for dry powder inhalation aerosol delivery [O] . Heidi Mansour, Don Hayes 2013

机译：有机溶液的物理化学表征和气溶胶分散性能先进的喷雾干燥环孢菌素用于干粉吸入气溶胶递送的多功能颗粒

Understanding the process-product-performance interplay of spray dried drug-polymer systems through complete structural and chemical characterization of single spray dried particles

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