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首页> 外文期刊>Paediatric anaesthesia >Median effective dose of intranasal dexmedetomidine sedation for transthoracic echocardiography in pediatric patients with noncyanotic congenital heart disease: An up‐and‐down sequential allocation trial
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Median effective dose of intranasal dexmedetomidine sedation for transthoracic echocardiography in pediatric patients with noncyanotic congenital heart disease: An up‐and‐down sequential allocation trial

机译：非胞间心绞痛小儿患者鼻内超声心动图中的中位数鼻内甲状腺嘌呤镇静剂镇静剂：下降顺序分配试验

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Summary <section numbered="no" xml:id="pan13235-sec-0001"> <title type="main">Background >Intranasal dexmedetomidine can provide adequate sedation during short procedures. However, previous literature investigating the single‐dose use of intranasal dexmedetomidine for sedation during transthoracic echocardiography in younger children is scarce, and the effects of age on sedation with intranasal dexmedetomidine remain controversial. </section> <section numbered="no" xml:id="pan13235-sec-0002"> <title type="main">Objective >This study was to determine the 50% effective dose and estimate the 95% effective dose of single‐dose intranasal dexmedetomidine to induce sedation in pediatric patients with noncyanotic congenital heart disease, and also determine the effect of age on the dose required for sedation. </section> <section numbered="no" xml:id="pan13235-sec-0003"> <title type="main">Methods > Patients were stratified into three age groups of 1‐6?months, 7‐12?months, and 13‐36?months. Intranasal dexmedetomidine started at a dose of 2?μg?kg ?1 on the first patient. The dose of dexmedetomidine for each subsequent patient was determined by the previous patient's response using Dixon's up‐and‐down method with an interval of 0.25?μg?kg ?1 . Sedation scale and recovery were assessed by the Modified Observer Assessment of Alertness and Sedation Scale and Modified Aldrete Recovery Score. The 50% effective dose was determined by Dixon's up‐and‐down method. In addition, both 50% effective dose and 95% effective dose were obtained using a probit regression approach. Other variables included sedation onset time, echocardiography time, wake‐up time, discharge time, heart rate, blood pressure, oxygen saturation, respiratory rate, and adverse events such as vomiting, regurgitation, and apnea. </section> <section numbered="no" xml:id="pan13235-sec-0004"> <title type="main">Results > The study population was comprised of 70 patients. The 50% effective dose (95% confidence interval) and the 95% effective dose (95% confidence interval) of intranasal dexmedetomidine for sedation were 1.8 (1.58‐2.00) μg?kg ?1 and 2.2 (1.92‐5.62) μg?kg ?1 in patients aged 1‐6?months, 1.8 (1.61‐1.95) μg?kg ?1 and 2.1 (1.90‐2.85) μg?kg ?1 in patients aged 7‐12?months, 2.2 (1.92‐2.37) μg?kg ?1 and 2.7 (2.34‐6.88) μg?kg ?1 in patients aged 13‐36?months, respectively. The 50% effective dose in age group 13‐36?months was higher than those of age group 1‐6?months ( P ?=?.042) and 7‐12?months ( P ?=?.043). There were no differences in sedation onset time, echocardiography time, wake‐up time, and discharge time between groups. None of the patients experienced oxyhemoglobin desaturation, hypotension, or bradycardia during the procedure. No significant adverse events occurred. </section> <section numbered="no" xml:id="pan13235-sec-0005"> <title type="main">Conclusion >Single‐dose of intranasal dexmedetomidine was an effective agent for patients under the age of 3?years requiring sedation for transthoracic echocardiography. The 50% effective dose of intranasal dexmedetomidine for transthoracic echocardiography sedation in children aged 13‐36?months was higher than in children 13?months. </section> </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><abstract xmlns =“http://www.wiley.com/namespaces/wiley”type =“main”xml：id =“pan13235-abs-0001”> <标题类型=“main”>摘要</ title> < Numbyed =“否”XML：ID =“Pan13235-SEC-0001”> <标题类型=“main”>背景</标题> >鼻内德克梅妥莫啶可以在短程中提供足够的镇静。然而，先前的文献研究了在较年轻的儿童的Transthoracorace超声心动图中，研究单剂量使用鼻内Dexmedetomidine用于镇静的贫困，并且年龄与intranasal dexmedetomidine镇静的影响仍然存在争议。</ p> </ section> <截面编号=“否“XML：ID =”Pan13235-SEC-0002“> <标题类型=”main“>目标</标题> >本研究是确定50％有效剂量并估计95％有效剂量的单一 - 剂量intxmasal dexmedetomidine诱导非胞外心囊疾病的儿科患者镇静，并确定年龄对镇静所需剂量的效果。</ p> </ section> <secteneded =“no”xml：id =“pan13235 -sec-0003“> <标题类型=”main“>方法</ title> >患者分层为1-6个月，7-12个月，7-36个月，13-36个月。在第一患者上以2·μg≤kgα1-/ sup>的剂量开始，鼻内甲状腺嘌呤甲基甲基medetomidine开始。通过先前的患者的上下方法测定每个后续患者的右氧化丙胺的剂量，使用Dixon的上下方法，间隔为0.25Ωμg≤kgΔ1。通过修改的观察者评估警觉和镇静规模和修改的次数恢复得分评估镇静规模和恢复。通过Dixon的上下方法测定50％的有效剂量。此外，使用概率回归方法获得50％有效剂量和95％有效剂量。其他变量包括镇静发作时间，超声心动图时间，唤醒时间，放电时间，心率，血压，氧饱和度，呼吸速率和不良事件，如呕吐，反流性和呼吸暂停等不良事件。 </ p> </段> <部分编号=“否”XML：ID =“PAN13235-SEC-0004”> <标题类型=“main”>结果</标题> >学习人群组成为70耐心。 50％有效剂量（95％置信区间）和95％有效剂量（95％的有效剂量（95％置信区间）用于镇静的鼻内甲基medetomidine为1.8（1.58-2.00）μg≤kgα1</ sup>和2.2（ 1.92-5.62）μg？kg α1</ sup>患者1-6岁的患者？月，1.8（1.61-1.95）μg？kg ？1 </ sup>和2.1（1.90-2.85） 7-12岁的患者μg？kg ？1 </ sup>，2.2（1.92-2.37）μg？kg Δ1</ sup>和2.7（2.34-6.88）μg？kg <在13-36岁的患者中，Sup> 1 </ sup>分别为13-36岁的患者。年龄组的50％有效剂量为13-36岁？月高于年龄组1-6〜6岁？月（ p </ i>？=α.042）和7-12个月（ p </ i>？=α.043）。镇静发作时间，超声心动图时间，唤醒时间和组之间的放电时间没有差异。患者均未在该程序期间经历过氧杂环蛋白去饱和度，低血压或心动过缓。没有发生重大不良事件。 </ p> </段> <部分编号=“否”XML：ID =“PAN13235-SEC-0005”> <标题类型=“main”>结论</标题> >单剂量intranasal dexmedetomidine是3年龄为3年龄的患者的有效剂，需要镇静进行静态超声心动图。在13-36岁儿童儿童中进行50％有效剂量的Transthorace超声心动图镇静镇静剂，比儿童高于儿童＆ 13个月。</ p> </段> </摘要> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-29618/'>《Paediatric anaesthesia》</a> <b style="margin: 0 2px;">|</b><span>2017年第11期</span><b style="margin: 0 2px;">|</b><span>共7页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Yu Qing&option=202" target="_blank" rel="nofollow">Yu Qing;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Liu Yang&option=202" target="_blank" rel="nofollow">Liu Yang;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Sun Mang&option=202" target="_blank" rel="nofollow">Sun Mang;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Zhang Jing&option=202" target="_blank" rel="nofollow">Zhang Jing;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Zhao Yan&option=202" target="_blank" rel="nofollow">Zhao Yan;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Liu Fengzhi&option=202" target="_blank" rel="nofollow">Liu Fengzhi;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Li Shangyingying&option=202" target="_blank" rel="nofollow">Li Shangyingying;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Tu Shengfen&option=202" target="_blank" rel="nofollow">Tu Shengfen;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Department of AnesthesiologyMinistry of Education Key Laboratory of Child Development and;</p> <p>Department of AnesthesiologyMinistry of Education Key Laboratory of Child Development and;</p> <p>Department of AnesthesiologyMinistry of Education Key Laboratory of Child Development and;</p> <p>Department of AnesthesiologyMinistry of Education Key Laboratory of Child Development and;</p> <p>Department of AnesthesiologyMinistry of Education Key Laboratory of Child Development and;</p> <p>Department of AnesthesiologyMinistry of Education Key Laboratory of Child Development and;</p> <p>Department of AnesthesiologyMinistry of Education Key Laboratory of Child Development and;</p> <p>Department of AnesthesiologyMinistry of Education Key Laboratory of Child Development and;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/5997.html" title="麻醉学">麻醉学;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=dexmedetomidine&option=203" rel="nofollow">dexmedetomidine;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=intranasal administration&option=203" rel="nofollow">intranasal administration;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=median effective dose&option=203" rel="nofollow">median effective dose;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=sedation&option=203" rel="nofollow">sedation;</a> </p> <div class="translation"> 机译：Dexmedetomidine;鼻内给药;中位有效剂量;镇静; </div> </li> </ul> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul> <li class="active" >外文文献</li> </ul> </div> <div class="similarity_details"> <ul > <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704024557812.html">Median effective dose of intranasal dexmedetomidine sedation for transthoracic echocardiography in pediatric patients with noncyanotic congenital heart disease: An up‐and‐down sequential allocation trial</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Yu Qing&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Yu Qing,</a> <a 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href="/open-access_resources_thesis/01000127768019.html">ED50 of Intranasal Dexmedetomidine Sedation for Transthoracic Echocardiography in Children with or without a History of Cardiac Surgery for Cyanotic Congenital Heart Disease</a> <b>[O] </b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=HongBin Gu&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">HongBin Gu,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=YunAn Song&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">YunAn Song,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Jie Bai&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Jie Bai </a> <span>2020</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：intanasal 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