pH-sensitive carbon quantum dots-doxorubicin nanoparticles for tumor cellular targeted drug delivery

摘要

A kind of pH-responsive carbon quantum dots-doxorubicin nanoparticles drug delivery platform (D-Biotin/DOX-loaded mPEG-OAL/N-CQDs) was designed and synthesized. The system consists of fluorescent carbon dots as cross-linkers, and D-Biotin worked as targeting groups, which made the system have a pH correspondence, doxorubicin hydrochloride (DOX) as the target drug, oxidized sodium alginate (OAL) as carrier materials. Ultraviolet (UV)-Vis spectrum showed that the drug-loading rate of DOX is 10.5%, and the drug release in vitro suggested that the system had a pH response and tumor cellular targeted, the drug release rate is 65.6% at the value of pH is 5.0, which is much higher than that at the value of pH is 7.4. The cytotoxicity test and laser confocal fluorescence imaging showed that the synthesized drug delivery system has high cytotoxicity to cancer cells, and the drug-loaded nanoparticles could enter the cells through endocytosis.