Universality of Micromolar-Level Cell-Based Hydrogen Peroxide Generation during Direct Cold Atmospheric Plasma Treatment

摘要

Understanding the interaction between cold atmospheric plasma (CAP) and cells is a critical challenge in plasma medicine. CAP has shown promising application for cancer treatment. To date, dozens of cancer cells have been selectively killed during in vitro studies, and CAP-originated reactive species have been regarded to be the primary factor causing cancer cell death. In the past, we investigated hydrogen peroxide (H,O_2) generation at the micromolar level using two CAP-treated cancer cell lines. In this study, we further demonstrate the universality of such strong cell-based H,O_2 generation in eight cancer cell lines.