Innovative Microcapsules for Pancreatic beta-Cells Harvested from Mature Double-Transgenic Mice: Cell Imaging, Viability, Induced Glucose-Stimulated Insulin Measurements and Proinflammatory Cytokines Analysis

摘要

Recently we demonstrated that microencapsulation of a murine pancreatic beta-cell line using an alginate-ursodeoxycholic acid (UDCA) matrix produced microcapsules with good stability and cell viability. In this study, we investigated if translation of this formulation to microencapsulation of primary beta-cells harvested from mature double-transgenic healthy mice would also generate stable microcapsules with good cell viability.