DRUG SYNTHESIS METHODS AND MANUFACTURING TECHNOLOGY INCREASES IN THE SOLUBILITY OF MEZAPAM BY FORMING SOLID DISPERSIONS

摘要

The effects of solid dispersions (SD) on the solubility of Mezapam were investigated. Mezapam and its SD with polyethylene glycol 1500, polyvinylpyrrolidone 10,000, and beta-cyclodextrin were studied. These SD increased the solubility and rate of dissolution of Mezapam. The solubility of Mezapam from SD increased by factors of 2-8. The rate of dissolution of Mezapam form SD increased by factors of 2-4. Use of a set of physicochemical study methods suggested that the improvements in the release of Mezapam from SD occurred as a result of decreases in crystallinity and increases in the formation of intermolecular complexes.