Gas‐Generating, pH‐Responsive Calcium Carbonate Hybrid Particles with Biomimetic Coating for Contrast‐Enhanced Ultrasound Imaging

摘要

Abstract > This work reports the fabrication of biocompatible and pH‐sensitive hybrid polydopamine/bovine serum albumin/calcium carbonate (PDA/BSA/CaCO <sub>3</sub> ) particles via a rapid precipitation method. These hybrid particles generate hyperechogenic carbon dioxide bubbles upon exposure to low pH environments, making them ideal as a contrast agent and detector for tumor cells. This study also highlights the application of red blood cell membrane (RBC)‐derived membranes as a biomimetic coating for PDA/BSA/CaCO <sub>3</sub> hybrid particles in order to modulate protein corona formation, a natural physiological response that alters tailored properties of most nanomaterials that are administered systemically. Results of this work demonstrate that the RBC membrane‐coated hybrid particles are ideal for a wide range of biomedical applications, such as noninvasive multimodal imaging, photothermal and photodynamic therapy, and “personalized” drug delivery systems. </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract Type =“Main”XML：Lang =“en”> <标题类型=“main”>抽象</ title> > 这项工作报告了生物相容性和pH敏感性杂交多斑嗪/牛血清白蛋白/碳酸钙（PDA / BSA / CACO）的制备 <sub> 3 </ sub> ）通过快速沉淀法的颗粒。这些杂化颗粒在暴露于低pH环境时产生高替代二氧化碳泡，使其成为肿瘤细胞的造影剂和检测器。本研究还突出了红细胞膜（RBC）的膜作为PDA / BSA / Caco的仿真涂层的应用 <sub> 3 </ sub> 杂交颗粒为了调节蛋白质电晕形成，自然的生理反应，其改变全身施用的大多数纳米材料的定制性质。该工作的结果表明RBC膜涂覆的混合颗粒是广泛的生物医学应用的理想选择，例如非侵入式多式化成像，光热和光动力疗法，以及“个性化”的药物递送系统。 </ p> </摘要> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-28901/'>《Particle & Particle Systems Characterization: Measurement and Description of Particle Properties and Behavior in Powders and Other Disperse Systems》</a> <b style="margin: 0 2px;">|</b><span>2020年第2期</span><b style="margin: 0 2px;">|</b><span>共8页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/6960.html" title="特种结构材料">特种结构材料;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=calcium carbonate nanoparticles&option=203" rel="nofollow">calcium carbonate nanoparticles;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=contrast enhanced ultrasound imaging&option=203" rel="nofollow">contrast enhanced ultrasound imaging;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=protein corona&option=203" rel="nofollow">protein corona;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=red blood cell membranes&option=203" rel="nofollow">red blood cell membranes;</a> </p> <div class="translation"> 机译：碳酸钙纳米粒子;对比增强超声成像;蛋白质电晕;红细胞膜; </div> </li> </ul> </div> </div> <div class="literature cardcommon" id="literaturereference" style="display:none"> <div class="similarity "> <h3 class="all_title" id="enpatent111">引文网络</h3> <div class="referencetab clearfix"> <ul id="referencedaohang"> <li dataid="referenceul">参考文献</li> <li dataid="citationul">引证文献</li> <li dataid="commonreferenceul">共引文献</li> <li dataid="commoncitationul">同被引文献</li> <li dataid="tworeferenceul">二级参考文献</li> <li dataid="twocitationul">二级引证文献</li> </ul> </div> <div class="reference_details" id="referenceList"> <ul id="referenceul"></ul> <ul id="citationul"></ul> <ul id="commonreferenceul"></ul> <ul id="commoncitationul"></ul> <ul id="tworeferenceul"></ul> <ul id="twocitationul"></ul> </div> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul> <li class="active" >外文文献</li> <li >中文文献</li> <li >专利</li> </ul> </div> <div class="similarity_details"> <ul > <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704024384946.html">Contrast‐Enhanced Ultrasound Imaging: Gas‐Generating, pH‐Responsive Calcium Carbonate Hybrid Particles with Biomimetic Coating for Contrast‐Enhanced Ultrasound Imaging (Part. Part. Syst. Charact. 2/2020)</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> </a> <a href="/journal-foreign-28901/" target="_blank" rel="nofollow" class="tuijian_authcolor">Particle & Particle Systems Characterization: Measurement and Description of Particle Properties and Behavior in Powders and Other Disperse Systems .</a> <span>2020</span><span>,第2期</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：对比度增强超声成像：气体产生，pH响应碳酸钙杂化颗粒，用于对比增强的超声成像（部分。部分。syst。挑战。2/2020）</span> </p> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704025681648.html">Biodegradable pH-responsive amorphous calcium carbonate nanoparticles as immunoadjuvants for multimodal imaging and enhanced photoimmunotherapy</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Wang Meng&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Wang Meng,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Zhou Benqing&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Zhou Benqing,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Wang Lu&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Wang Lu,</a> <a href="/journal-foreign-35177/" target="_blank" rel="nofollow" class="tuijian_authcolor">Journal of Materials Chemistry, B. materials for biology and medicine .</a> <span>2020</span><span>,第36期</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：可生物降解的pH-响应无定形碳酸钙纳米粒子作为多峰成像的免疫谐腾和增强的光疗法</span> </p> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704027906882.html">Oxygen-generating hybrid nanoparticles to enhance fluorescent/photoacoustic/ultrasound imaging guided tumor photodynamic therapy</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Gao Shi&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Gao Shi,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Wang Guohao&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Wang Guohao,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Qin Zainen&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Qin Zainen,</a> <a href="/journal-foreign-14829/" target="_blank" rel="nofollow" class="tuijian_authcolor">Biomaterials .</a> <span>2017</span><span>,第期</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：氧生成杂化纳米颗粒以增强荧光/光声/超声成像引导肿瘤光动力治疗</span> </p> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/academic-conference-foreign_meeting-252094_thesis/070508770842.html">Osteo-integration of plasma-spray, biomimetic octacalcium phosphate and carbonate-apatite coatings on titanium implants</a> <b>[C]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=P. Habibovic&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">P. Habibovic,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=C. M. van der Valk&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">C. M. van der Valk,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=K. De Groot&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">K. De Groot,</a> <a href="/conference-foreign-252094/" target="_blank" rel="nofollow" class="tuijian_authcolor">International Symposium on Ceramics in Medicine .</a> <span>2003</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：钛植入物上的血浆喷雾，仿生八氯铵磷酸盐和碳酸盐 - 磷灰石涂料的骨质 - 植入物</span> </p> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/academic-degree-foreign_mphd_thesis/0206135786.html">Speckle tracking for cardiac strain imaging in ultrasound imaging and contrast enhancement in photoacoustic imaging.</a> <b>[D] </b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Jia, Congxian.&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Jia, Congxian. </a> <span>2010</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：用于超声成像中的心脏应变成像的斑点跟踪和光声成像中的对比度增强。</span> </p> </li> <li> <div> <b>6. </b><a class="enjiyixqcontent" href="/academic-journal-foreign-pmc_detail_thesis/04000964487.html">Mitoxantrone-preloaded water-responsive phospholipid-amorphous calcium carbonate hybrid nanoparticles for targeted and effective cancer therapy</a> <b>[O] </b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Cheng Wang&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Cheng Wang,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Min Han&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Min Han,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Xuerong Liu&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Xuerong Liu,</a> <span>2019</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：米托蒽醌预载的水响应性磷脂-无定形碳酸钙杂化纳米颗粒用于靶向和有效的癌症治疗</span> </p> </li> <li> <div> <b>7. </b><a class="enjiyixqcontent" href="/open-access_resources_thesis/01000126611173.html">Contrast‐Enhanced Ultrasound Imaging: Gas‐Generating, pH‐Responsive Calcium Carbonate Hybrid Particles with Biomimetic Coating for Contrast‐Enhanced Ultrasound Imaging (Part. Part. Syst. Charact. 2/2020)</a> <b>[O] </b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Mark Louis P. Vidallon&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Mark Louis P. Vidallon,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Alon M. Douek&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Alon M. Douek,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Adam Quek&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Adam Quek,</a> <span>2020</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：对比度增强超声成像：气体产生，pH响应碳酸钙杂化颗粒，具有用于对比增强的超声成像的仿生涂层（部分。部分。SYPT。FALACT。2/2020）</span> </p> </li> </ul> <ul style="display: none;"> <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/academic-journal-cn_china-powder-industry_thesis/0201291394955.html">小颗粒,办大事!医疗用纳米碳酸钙“擦亮”超声成像,“便捷”药物传递</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . </a> <span> <a href="/journal-cn-7732/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 中国粉体工业 </a> </span> <span> . 2021</span><span>,第005期</span> </span> </div> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/academic-journal-cn_journal-henan-normal-university-natural-science-edition_thesis/0201294592326.html">菊糖水溶液中具有分级结构碳酸钙的仿生合成与表征</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=张晓婷&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 张晓婷</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=王魁&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,王魁</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=马晓明&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,马晓明</a> <span> <a href="/journal-cn-50501/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 河南师范大学学报：自然科学版 </a> </span> <span> . 2014</span><span>,第4期</span> </span> </div> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/academic-journal-cn_journal-henan-normal-university-natural-science-edition_thesis/0201295534834.html">大豆胰岛素指导下具有分级结构碳酸钙的仿生合成</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=马晓明&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 马晓明</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=杨媛媛&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,杨媛媛</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=张晓婷&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,张晓婷</a> <span> <a href="/journal-cn-50501/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 河南师范大学学报：自然科学版 </a> </span> <span> . 2014</span><span>,第2期</span> </span> </div> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/academic-journal-cn_journal-hubei-university-natural-science_thesis/0201288421469.html">功能性上转换纳米颗粒NaYF4:Yb/Tm用于潜在的荧光成像和pH响应药物递送</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=许明悦&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 许明悦</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=田丰&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,田丰</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=高海清&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,高海清</a> <span> <a href="/journal-cn-4612/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 湖北大学学报（自然科学版） </a> </span> <span> . 2021</span><span>,第003期</span> </span> </div> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/academic-journal-cn_chinese-journal-applied-chemistry_thesis/0201272095132.html">均匀大颗粒球形碳酸钙的仿生合成</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=陈先勇&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 陈先勇</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=唐琴&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,唐琴</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=胡卫兵&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,胡卫兵</a> <span> <a href="/journal-cn-54377/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 应用化学 </a> </span> <span> . 2009</span><span>,第005期</span> </span> </div> </li> <li> <div> <b>6. </b><a class="enjiyixqcontent" href="/academic-conference-cn_meeting-43337_thesis/020222759599.html">具有聚多巴胺-银纳米颗粒/丝素蛋白-庆大霉素涂层的三维多孔聚醚醚酮表面增强的生物相容性和抗菌性</a> <b>[C]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=鄢江龙&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 鄢江龙</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=成艳&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,成艳</a> <span> <a href="/conference-cn-43337/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 2017中国生物材料大会 </a> <span> <span> . 2017</span> </span> </div> </li> <li> <div> <b>7. </b><a class="enjiyixqcontent" href="/academic-degree-domestic_mphd_thesis/020313134195.html">生物矿化后具有pH响应性的硫化亚铁纳米颗粒用于肿瘤多模态成像及热放疗-化疗协同治疗的研究</a> <b>[A] </b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=沈佳&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 沈佳</a> <span> . 2017</span> </span> </div> </li> </ul> <ul style="display: none;"> <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/patent-detail/06120110015488.html">一种应用于药物缓释系统的微球形且具有pH响应的壳聚糖/碳酸钙的制备方法</a> <b>[P]</b> . <span> 中国专利： CN107536806A </span> <span> . 2018-01-05</span> </div> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/patent-detail/06120113797587.html">一种具有pH响应功能的抗菌涂层、具有抗菌涂层的功能材料及其制备方法</a> <b>[P]</b> . <span> 中国专利： CN113801568A </span> <span> . 2021-12-17</span> </div> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/patent-detail/06130411386809.html">A photosensitizer-loaded calcium carbonate hybrid nanoparticle a preparation method thereof and a composition for ultrasound contrast imaging and photodynamic therapy comprising the same</a> <b>[P]</b> . <span> 外国专利：  KR101622031B1 </span> <span> . 2016-05-19</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：负载光敏剂的碳酸钙杂化纳米颗粒，其制备方法以及用于超声造影成像和光动力疗法的组合物 </span> </p> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/patent-detail/06130411543438.html">A PHOTOSENSITIZER-LOADED CALCIUM CARBONATE HYBRID NANOPARTICLE, A PREPARATION METHOD THEREOF AND A COMPOSITION FOR ULTRASOUND CONTRAST IMAGING AND PHOTODYNAMIC THERAPY COMPRISING THE SAME</a> <b>[P]</b> . <span> 外国专利：  KR20160013474A </span> <span> . 2016-02-04</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：光敏化负载碳酸钙混合纳米粒子，其制备方法及组成相同的超声造影和光动力疗法的组合物 </span> </p> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/patent-detail/06130416884184.html">A pH-sensitive calcium carbonate hybrid nanoparticle, a preparation method thereof and a composition for ultrasound contrast comprising the same</a> <b>[P]</b> . <span> 外国专利：  KR101336504B1 </span> <span> . 2013-12-03</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：pH敏感的碳酸钙杂化纳米颗粒，其制备方法和包含该纳米颗粒的超声造影剂组合物 </span> </p> </li> </ul> </div> </div> </div> <div class="theme cardcommon" style="overflow: auto;display:none"> <h3 class="all_title" id="enpatent55">相关主题</h3> <ul id="subject"> </ul> </div> </div> </div> </div> <div class="right rightcon"> <div class="details_img cardcommon clearfix" style="margin-bottom: 10px;display:none;" > </div> </div> </div> <div id="thesis_get_original1" class="downloadBth" style="bottom: 19px;z-index: 999;" onclick="ywcd('0704024384539','4',7,2,1,'',this,24)" class="delivery" prompt="010401" title="通过人工服务将文献原文发送至邮箱" >获取原文</div> <div class="journalsub-pop-up" style="display: none"> <div class="journal-sub"> <h2>期刊订阅</h2> <img src="https://cdn.zhangqiaokeyan.com/img/loginclose.png" alt="关闭" onclick="$('.journalsub-pop-up').hide()"> <p class="pardon">抱歉，该期刊暂不可订阅，敬请期待！</p> <p class="current">目前支持订阅全部北京大学中文核心（2020）期刊目录。</p> <div style="display: flex;margin-top: 69px;justify-content: space-between;"> <div class="no-sub" onclick="$('.journalsub-pop-up').hide()">暂不订阅</div> <div class="other-sub" onclick="continueSub('from=pc-detail')">继续订阅其他期刊</div> </div> </div> </div> <div class="right_btn"> <ul> <li class="gouwuche">  </li> <li class="yijian"> <a href="javascript:void(0);" onclick="link_analysis('/mycenter/auth/complaint.html',this)" title="意见反馈">意见反馈</a> </li> <li class="top"> <a href="javascript:scrollTo(0,0);" title="回到顶部">回到顶部</a> </li> <li class="shouye"> <a href="/" title="首页">回到首页</a> </li> </ul> </div> <div class="xllindexfooter"> <div class="xllindexfootercenter"> <div class="xllindexfooterleft left" > <div class="xllindexfooterleftli"> <ul> <li><a href="/about.html" title="关于掌桥">关于掌桥</a></li> <li><a href="/help/helpmap.html" title="资源导航">资源导航</a></li> <li><a href="/help/helpguide.html" title="新手指南">新手指南</a></li> <li><a href="/help/helpcenter.html" title="常见问题">常见问题</a></li> <li><a href="/sitemap.html" title="网站地图">网站地图</a></li> <li><a href="/help/helpcenter.html?type=9" title="版权声明">版权声明</a></li> </ul> </div> <div class="xllindexfooterleft"> <p class="xllindexfooterlefteamil">客服邮箱：kefu@zhangqiaokeyan.com</p> <div class="xllindexfooterlefttcp"> <div class="xllindexfooterpoliceiimg"></div> <div class="xllindexfooterpoliceispan"> <span>京公网安备：11010802029741号 </span> <span>ICP备案号：<a href="https://beian.miit.gov.cn" rel="nofollow" target="_blank" title="ICP备案号">京ICP备15016152号-6</a></span> <span>六维联合信息科技 (北京) 有限公司©版权所有</span> </div> </div> </div> </div> <div class="xllindexfooterright left"> <ul> <li> <p style="font-weight: bold;">客服微信</p> <div></div> </li> <li> <p style="font-weight: bold;">服务号</p> <div></div> </li> </ul> </div> </div> </div> <span id="0704024384539down" data-source="7," data-out-id="8HkbUEExYGISxLM8TyqhLCBsMUClDCNyolxJgwp2Q2lWMzSuNafm1aLdQfSJLhEP," data-f-source-id="7" data-title="Gas‐Generating, pH‐Responsive Calcium Carbonate Hybrid Particles with Biomimetic Coating for Contrast‐Enhanced Ultrasound Imaging" data-price="20" data-site-name="" data-transnum="24" style="display:none;"></span> <input type="hidden" value="4" id="sourcetype"> <input type="hidden" value="0704024384539" id="docid"> <input type="hidden" value="28901" id="journalid"> <input type="hidden" value="1" id="inyn_provide_service_level"> <input type="hidden" value="https://cdn.zhangqiaokeyan.com" id="imgcdn"> <input type="hidden" value="1" id="isdeatail"> <input type="hidden" value="" id="syyn_indexed_database"> <input type="hidden" value="" id="servicetype"> <input type="hidden" id="pagename" value="Gas‐Generating, pH‐Responsive Calcium Carbonate Hybrid Particles with Biomimetic Coating for Contrast‐Enhanced Ultrasound Imaging"/> <input type="hidden" value="thesis_get_original" id="pageIdentification"> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/jquery-1.12.4.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/lwlh_ajax.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/zq.js?v=5.8.0"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/common.js?v=5.8.0"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/jquery.cookie.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/top.js?v=5.8.0"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/tip.js?v=5.8.0"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/login.js?v=5.8.0"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/down.js?v=5.8.0"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/search.js?v=5.8.0"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/newmail.js?v=5.8.0"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/page.js?v=5.8.0"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/searchtype.js?v=5.8.0"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/user/regist.js?v=5.8.0"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/zxs_solor/detail.js?v=5.8.0"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/zxs_solor/reference.js?v=5.8.0"></script> <script type="text/javascript" src="https://www.zhangqiaokeyan.com/statistics/static/pagecollection.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/tj.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/sse.js?v=5.8.0"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/pushbaidu.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/history.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/util/cookie.js?v=5.8.0"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/weipu/weipu.js?v=5.8.0"></script> </body> <script> $(function(){ var weiPuStatus = getCookie('WeiPuStatus'); if(weiPuStatus){ tipWeiPuStatus(weiPuStatus); delCookie('WeiPuStatus'); } getFacetKeywordVoInId(); var sourcetype = $("#sourcetype").val(); var inyn_provide_service_level = $("#inyn_provide_service_level").val(); if((sourcetype ==1||sourcetype==4)&&inyn_provide_service_level!=4){ getJournal(); } }) </script> </html>