Construction of a Dual Drug Carrier on the Basis of Hollow Structured Upconversion Nanoparticles for pH‐Responsive Drug Delivery and UCL/MRI Dual Mode Imaging

Liu Yana; Feng Yiming; Xu Chen; He Hailu; Zhang Yongqi; Xu Zushun; Li Ling; Wang Jing

摘要

Abstract > A series of Gd 3+ doping hollow upconversion nanoparticles NaYF <sub>4</sub> :Yb,Gd,Tm (h‐UNCP) are prepared successfully. The hollow NaYF <sub>4</sub> :Yb,Gd,Tm possess excellent upconversion luminescence (UCL) and large longitudinal relativity ( r <sub>1</sub> = 128.3 m <sc>m</sc> ?1 s ?1 ), which can be potentially used for UCL/magnetic resonance imaging (MRI) dual mode imaging. On the basis of the optimal h‐UCNP, doxorubicin hydrochloride (DOX) and methotrexate (MTX) are used as drug models to prepare a dual drug carrier. After the encapsulation of DOX on the h‐UCNP, chitosan (CS) is further wrapped and then used to load MTX to obtain a dual drug carrier h‐UCNPs/DOX/CS/MTX. The pH responsive release of DOX and MTX is discussed. The MTX release climbs from 33% to 100% by regulating the pH from 5.8 to 7.4. The DOX release is different at different pH conditions. The synergistic effect of DOX and MTX on the cancer cells is confirmed by cell viability. The h‐UCNPs/DOX/CS/MTX are tracked by cells UCL imaging and vivo MRI imaging. The excellent performance of UCL imaging and positive MRI images demonstrates that h‐UCNPs/DOX/CS/MTX can be used for UCL/MRI dual mode imaging. All the results show the potential application of h‐UCNPs/DOX/CS/MTX in pH responsive release and UCL/MRI dual imaging. </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract Type =“Main”XML：Lang =“en”> <标题类型=“main”>抽象</ title> > 一系列GD 3 + </ sup> 掺杂中空升级纳米颗粒Nayf <sub> 4 </ sub> ：YB，GD，TM（H-UNFP）成功制备。空洞的nayf. <sub> 4 </ sub> ：YB，GD，TM具有优异的上转换发光（UCL）和大的纵向相对性（ R </ I> <sub> 1 </ sub> = 128.3米 <sc> m </ sc> ？1 </ sup> S. ？1 </ sup> ），其可能用于UCL /磁共振成像（MRI）双模成像。在最佳的H-UCNP的基础上，使用盐酸辛酸（DOX）和甲氨蝶呤（MTX）作为药物模型以制备双药物载体。在H-UCNP上封装DOX后，进一步包裹壳聚糖（CS），然后用于载有MTX以获得双药物载体H-UCNP / DOX / CS / MTX。讨论了DOX和MTX的pH响应释放。通过调节5.8至7.4的pH，MTX释放从33％升至100％。 DOX释放在不同的pH条件下不同。通过细胞活力证实了DOX和MTX对癌细胞上的协同作用。通过细胞UCL成像和体内MRI成像跟踪H-UCNPS / DOX / CS / MTX。 UCL成像和正线MRI图像的优异性能表明H-UCNP / DOX / CS / MTX可用于UCL / MRI双模成像。所有结果显示H-UCNPS / DOX / CS / MTX在pH响应释放和UCL / MRI双成像中的潜在应用。 </ p> </摘要> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" > 著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-28901/'>《Particle & Particle Systems Characterization: Measurement and Description of Particle Properties and Behavior in Powders and Other Disperse Systems 》</a> <b style="margin: 0 2px;">|</b><span>2019年第10期</span><b style="margin: 0 2px;">|</b> <span>共8页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Liu Yana&option=202" target="_blank" rel="nofollow">Liu Yana;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Feng Yiming&option=202" target="_blank" rel="nofollow">Feng Yiming;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Xu Chen&option=202" target="_blank" rel="nofollow">Xu Chen;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=He Hailu&option=202" target="_blank" rel="nofollow">He Hailu;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Zhang Yongqi&option=202" target="_blank" rel="nofollow">Zhang Yongqi;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Xu Zushun&option=202" target="_blank" rel="nofollow">Xu Zushun;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Li Ling&option=202" target="_blank" rel="nofollow">Li Ling;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Wang Jing&option=202" target="_blank" rel="nofollow">Wang Jing;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Ministry‐of‐Education Key Laboratory for the Synthesis and Application of Organic Function MoleculesHubei UniversityHubei 430062 P. R. China;</p> <p>Department of RadiologyHuazhong University of Science and TechnologyWuhan 430022 China;</p> <p>Ministry‐of‐Education Key Laboratory for the Synthesis and Application of Organic Function MoleculesHubei UniversityHubei 430062 P. R. China;</p> <p>Ministry‐of‐Education Key Laboratory for the Synthesis and Application of Organic Function MoleculesHubei UniversityHubei 430062 P. R. China;</p> <p>Ministry‐of‐Education Key Laboratory for the Synthesis and Application of Organic Function MoleculesHubei UniversityHubei 430062 P. R. China;</p> <p>Ministry‐of‐Education Key Laboratory for the Synthesis and Application of Organic Function MoleculesHubei UniversityHubei 430062 P. R. China;</p> <p>Ministry‐of‐Education Key Laboratory for the Synthesis and Application of Organic Function MoleculesHubei UniversityHubei 430062 P. R. China;</p> <p>Department of RadiologyHuazhong University of Science and TechnologyWuhan 430022 China;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li> <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span> <a href="https://www.zhangqiaokeyan.com/clc/6960.html" title="特种结构材料">特种结构材料 ;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=dual drug delivery&option=203" rel="nofollow">dual drug delivery;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=dual modal imaging&option=203" rel="nofollow">dual modal imaging;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Gd&option=203" rel="nofollow">Gd;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=hollow upconversion nanoparticles&option=203" rel="nofollow">hollow upconversion nanoparticles;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=NaYF4:Yb&option=203" rel="nofollow">NaYF4:Yb;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=pH responsive&option=203" rel="nofollow">pH responsive;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Tm&option=203" rel="nofollow">Tm;</a> </p> <div class="translation"> 机译：双重药物递送;双模型成像;GD;中空上链纳米颗粒;Nayf4：YB;响应;TM; </div> </li> </ul> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div 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href="/patent-detail/06120100064454.html">一种基于双模板分子印迹技术的pH响应荧光型药物递送系统的制备方法</a> <b>[P]</b> . <span> 中国专利： CN109432446A </span> <span> . 2019-03-08</span> </div> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/patent-detail/061201857559.html">基于铁氧化物纳米颗粒的用于淋巴系统造影术的MRI对比剂和使用所述MRI对比剂用于使淋巴结成像的方法</a> <b>[P]</b> . <span> 中国专利： CN103458932B </span> <span> . 2015.12.09</span> </div> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/patent-detail/06130408609851.html">UV- pH - DUAL STIMULI-RESPONSIVE CORE-SHELL MAGNETIC NANOPARTICLE HAVING UV-LIGHT RESPONSIVITY AND pH-RESPONSIVITY AND DRUG DELIVERY COMPISING THE SAME</a> <b>[P]</b> . <span> 外国专利：  KR101725240B1 </span> <span> . 2017-04-11</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：紫外线-pH-具有紫外线响应性和pH响应性的双重刺激反应性壳核磁性纳米颗粒和药物递送 </span> </p> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/patent-detail/06130411442412.html">UV- pH - DUAL STIMULI-RESPONSIVE CORE-SHELL MAGNETIC NANOPARTICLE HAVING UV-LIGHT RESPONSIVITY AND pH-RESPONSIVITY AND DRUG DELIVERY COMPISING THE SAME</a> <b>[P]</b> . <span> 外国专利：  KR20160114476A </span> <span> . 2016-10-05</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：紫外线-pH-具有紫外线响应性和pH响应性的双重刺激反应性壳核磁性纳米颗粒和药物递送 </span> </p> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/patent-detail/06130419422521.html">DUAL TRANSITION POLYMER HYDROGEL HAVING DUAL TRANSITION CHARACTERISTICS VARYING WITH PH AND BEING APPLIED AS A DRUG DELIVERY AGENT FOR HYDROPHILIC DRUGS OR HYDROPHOBIC DRUGS AND A USE THEREOF</a> <b>[P]</b> . <span> 外国专利：  KR20130090950A </span> <span> . 2013-08-16</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：具有具有随PH值变化的双重转变特性的双转变聚合物水，并且被用作亲水性或疏水性药物的药物转运剂及其用途 </span> </p> </li> </ul> </div> </div> </div> <div class="theme cardcommon" style="overflow: auto;display:none"> <h3 class="all_title" id="enpatent55">相关主题</h3> <ul id="subject"> </ul> </div> </div> </div> </div> <div class="right rightcon"> <div class="details_img cardcommon clearfix" style="margin-bottom: 10px;display:none;" > </div> </div> </div> <div id="thesis_get_original1" class="downloadBth" style="bottom: 19px;z-index: 999;" onclick="ywcd('0704024384472','4',7,2,1,'',this,24)" class="delivery" prompt="010401" title="通过人工服务将文献原文发送至邮箱" >获取原文</div> <div class="journalsub-pop-up" style="display: none"> <div class="journal-sub"> <h2>期刊订阅</h2> <img src="https://cdn.zhangqiaokeyan.com/img/loginclose.png" alt="关闭" onclick="$('.journalsub-pop-up').hide()"> <p class="pardon">抱歉，该期刊暂不可订阅，敬请期待！</p> <p class="current">目前支持订阅全部北京大学中文核心（2020）期刊目录。</p> <div style="display: 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