Arenobufagin Inhibits the Phosphatidylinositol 3-kinase/Protein Kinase B/Mammalian Target of Rapamycin Pathway and Induces Apoptosis and Autophagy in Pancreatic Cancer Cells

Wei Xiaolu; Yang Jian; Mao Yingqiu; Zhao Haiyu; Si Nan; Wang Hongjie; Bian Baolin

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Arenobufagin Inhibits the Phosphatidylinositol 3-kinase/Protein Kinase B/Mammalian Target of Rapamycin Pathway and Induces Apoptosis and Autophagy in Pancreatic Cancer Cells

机译：arenobufagin抑制磷脂蛋白途径的磷脂酰肌醇3-激酶/蛋白激酶B /哺乳动物靶标，并在胰腺癌细胞中诱导细胞凋亡和自噬

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摘要

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机译：客观的

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来源
《Pancreas》 |2020年第2期|共12页
作者
Wei Xiaolu; Yang Jian; Mao Yingqiu; Zhao Haiyu; Si Nan; Wang Hongjie; Bian Baolin;
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作者单位

China Acad Chinese Med Sci Inst Chinese Mat Med Key Lab Beijing Identificat &

Safety Evaluat Chin;

China Acad Chinese Med Sci Inst Chinese Mat Med Key Lab Beijing Identificat &

Safety Evaluat Chin;

Beijing Univ Chinese Med Beijing Res Inst Chinese Med Funct &

Morphol Lab Beijing Peoples R;

China Acad Chinese Med Sci Inst Chinese Mat Med Key Lab Beijing Identificat &

Safety Evaluat Chin;

China Acad Chinese Med Sci Inst Chinese Mat Med Key Lab Beijing Identificat &

Safety Evaluat Chin;

China Acad Chinese Med Sci Inst Chinese Mat Med Key Lab Beijing Identificat &

Safety Evaluat Chin;

China Acad Chinese Med Sci Inst Chinese Mat Med Key Lab Beijing Identificat &

Safety Evaluat Chin;

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原文格式 PDF
正文语种 eng
中图分类消化系及腹部疾病;
关键词
pancreatic cancer; arenobufagin; antitumor; apoptosis; autophagy; in vivo;

机译：胰腺癌;arenobufagin;抗肿瘤;细胞凋亡;自噬;在体内;

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专利

1. Arenobufagin Inhibits the Phosphatidylinositol 3-kinase/Protein Kinase B/Mammalian Target of Rapamycin Pathway and Induces Apoptosis and Autophagy in Pancreatic Cancer Cells [J] . Wei Xiaolu, Yang Jian, Mao Yingqiu, Pancreas . 2020,第2期

机译：arenobufagin抑制磷脂蛋白途径的磷脂酰肌醇3-激酶/蛋白激酶B /哺乳动物靶标，并在胰腺癌细胞中诱导细胞凋亡和自噬
2. Curcumin inhibits the growth of liver cancer stem cells through the phosphatidylinositol 3-kinase/protein kinase B/mammalian target of rapamycin signaling pathway [J] . Wang Ji, Wang Chunying, Bu Gaofeng Experimental and therapeutic medicine . 2018,第4aPta1期

机译：姜黄素抑制肝癌干细胞的生长通过磷脂酰肌醇3-激酶/蛋白激酶B /哺乳动物靶标在雷帕霉素信号传导途径
3. Gambogic acid suppresses hypoxia-induced hypoxia-inducible factor-1/vascular endothelial growth factor expression via inhibiting phosphatidylinositol 3-kinase/Akt/mammalian target protein of rapamycin pathway in multiple myeloma cells [J] . Wang Fei, Zhang Wei, Guo Liting, Cancer science. . 2014,第8期

机译：藤黄酸通过抑制多发性骨髓瘤细胞中雷帕霉素途径的磷脂酰肌醇3-激酶/ Akt /哺乳动物靶蛋白来抑制低氧诱导的低氧诱导因子-1 /血管内皮生长因子的表达。
4. Multifaceted activities of class Ⅰ phosphatidylinositol 3-kinase inhibitor ZSTK474 on human breast cancer cells [C] . Xin Peng, Zhengming Wang, Chang Zhou, International Forum on Leading Edge Technologies on Crystallization Engineering and Pharmaceutics Development;Tianjin University;Tianjin Medical University . -1

机译：Ⅰ类磷脂酰肌醇3-激酶抑制剂ZSTK474对人乳腺癌细胞的多丝活动
5. Preclinical evaluation of inhibitors of the phosphatidylinositide 3-kinase/protein kinase B cell survival pathway in the treatment of pancreatic cancer. [D] . Ng, Sylvia Sze Wai. 2002

机译：磷脂酰肌醇3激酶/蛋白激酶B细胞存活途径抑制剂在胰腺癌治疗中的临床前评价。
6. Knockdown of Hypoxia-Inducible Factor 1α (HIF-1α) Promotes Autophagy and Inhibits Phosphatidylinositol 3-Kinase (PI3K)/AKT/Mammalian Target of Rapamycin (mTOR) Signaling Pathway in Ovarian Cancer Cells [O] . Jinling Huang, Likun Gao, Bingshu Li, 2019

机译：敲低缺氧诱导因子1α（HIF-1α）促进自噬并抑制卵巢癌细胞中雷帕霉素（mTOR）信号通路的磷脂酰肌醇3-激酶（PI3K）/ AKT /哺乳动物靶标
7. Hydrogen Sulfide Attenuates High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease by Inhibiting Apoptosis and Promoting Autophagy via Reactive Oxygen Species/Phosphatidylinositol 3-Kinase/AKT/Mammalian Target of Rapamycin Signaling Pathway [O] . Dongdong Wu, Peiyu Zhong, Yizhen Wang, 2020

机译：通过抑制细胞凋亡和通过反应性氧物种/磷脂酰肌醇3-激酶/ Akt /哺乳动物催化催化毒素信号传导途径通过抑制高脂饮食诱导的非酒精脂肪肝病

Arenobufagin Inhibits the Phosphatidylinositol 3-kinase/Protein Kinase B/Mammalian Target of Rapamycin Pathway and Induces Apoptosis and Autophagy in Pancreatic Cancer Cells

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