Follow-up management of refractory continuous positive airway pressure therapy: Emergent periodic limb movements in sleep

摘要

A 48-year-old man with severe obstructive sleep apnea (OSA) had severe and refractory continuous positive airway pressure (CPAP)-emergent periodic limb movements in sleep (PLMS) [1 ] and excessive daytime sleepiness (EDS). During 28 months of follow-up management, single dopaminergic agents, single anticonvulsant and combination drug therapy were prescribed successively for PLMS. The final prescription of levodopa/benserazide combined with carbamazepine therapy successfully reduced PLMS and eliminated symptom of subjective EDS.