SAFETY, TOLERABILITY, AND EFFICACY OF A NOVEL, HIGHLY POTENT AND SELECTIVE PARTIAL AGONIST FOR NOCICEPTIN/ORPHANIN-FQ PEPTIDE (NOP) RECEPTORS IN PATIENTS WITH INSOMNIA DISORDER

Zhou M.; Harris S.; Kapil R.; Cipriano A.; He E.; Shet M.; Fukumura K.; Matsuo Y.; Uehira M.; Zammit G.

首页> 外文期刊>Sleep >SAFETY, TOLERABILITY, AND EFFICACY OF A NOVEL, HIGHLY POTENT AND SELECTIVE PARTIAL AGONIST FOR NOCICEPTIN/ORPHANIN-FQ PEPTIDE (NOP) RECEPTORS IN PATIENTS WITH INSOMNIA DISORDER

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SAFETY, TOLERABILITY, AND EFFICACY OF A NOVEL, HIGHLY POTENT AND SELECTIVE PARTIAL AGONIST FOR NOCICEPTIN/ORPHANIN-FQ PEPTIDE (NOP) RECEPTORS IN PATIENTS WITH INSOMNIA DISORDER

机译：新型，高度有效和选择性的部分激动剂对失眠症患者的伤害蛋白/孤儿林-FQ肽（NOP）受体的安全性，耐受性和有效性

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来源
《Sleep》 |2020年第1期|共1页
作者
Zhou M.; Harris S.; Kapil R.; Cipriano A.; He E.; Shet M.; Fukumura K.; Matsuo Y.; Uehira M.; Zammit G.;
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作者单位

Imbrium Therapeut Stamford CT USA;

Imbrium Therapeut Stamford CT USA;

Imbrium Therapeut Stamford CT USA;

Imbrium Therapeut Stamford CT USA;

Imbrium Therapeut Stamford CT USA;

Imbrium Therapeut Stamford CT USA;

Shionogi &

Co Ltd Osaka Japan;

Shionogi &

Co Ltd Osaka Japan;

Shionogi &

Co Ltd Osaka Japan;

Clinilabs Drug Dev Corp New York NY USA;

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原文格式 PDF
正文语种 eng
中图分类人体生理学;
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专利

1. SAFETY, TOLERABILITY, AND EFFICACY OF A NOVEL, HIGHLY POTENT AND SELECTIVE PARTIAL AGONIST FOR NOCICEPTIN/ORPHANIN-FQ PEPTIDE (NOP) RECEPTORS IN PATIENTS WITH INSOMNIA DISORDER [J] . Zhou M., Harris S., Kapil R., Sleep . 2020,第Suppla1期

机译：新型，高度有效和选择性的部分激动剂对失眠症患者的伤害蛋白/孤儿林-FQ肽（NOP）受体的安全性，耐受性和有效性
2. PSYCHOMOTOR/COGNITIVE EFFECTS, PHARMACOKINETICS AND SAFETY OF V117957, A NOVEL, HIGHLY POTENT AND SELECTIVE PARTIAL AGONIST FOR NOCICEPTIN/ORPHANIN-FQ PEPTIDE (NOP) RECEPTORS, ADMINISTERED IN COMBINATION WITH ALCOHOL IN HEALTHY SUBJECTS [J] . Zhou M., Harris S., Cipriano A., Sleep . 2020,第Suppla1期

机译：v117957的精神运动/认知效果，药代动力学和安全性，一种用于饥饿素/孤儿林-FQ肽（NOP）受体的新型，高效和选择性的部分激动剂，与健康受试者组合给药
3. EVALUATION OF THE HUMAN ABUSE POTENTIAL OF SINGLE ORAL DOSES OF V117957, A NOVEL, HIGHLY POTENT AND SELECTIVE PARTIAL AGONIST FOR NOCICEPTIN/ORPHANIN-FQ PEPTIDE (NOP) RECEPTORS [J] . Harris S., Zhou M., Cipriano A., Sleep . 2020,第Suppla1期

机译：评估单次口服剂量V117957的人类滥用潜力，一种用于伤害蛋白/孤儿林-FQ肽（NOP）受体的新型，高效和选择性的部分激动剂
4. Potent and selective peptide agonists for human melanocortin receptor 5 [C] . Maria A. Bednarek, Tanya MacNeil, Rui Tang American Peptide Symposium . 2009

机译：用于人黑色主酶受体5的有效和选择性肽激动剂
5. Design, synthesis, molecular modeling, and biological evaluation of novel NOP (nociceptin/orphanin FQ peptide) receptor ligands. [D] . Philip, Ashok E. 2006

机译：设计，合成，分子建模和新型NOP（nociceptin / orphanin FQ肽）受体配体的生物学评估。
6. C7β-MethylAnalogues of the Orvinols: The Discoveryof Kappa Opioid Antagonists with Nociceptin/Orphanin FQ Peptide (NOP)Receptor Partial Agonism and Low or Zero Efficacy at Mu Opioid Receptors [O] . Juan Pablo Cueva, §, Christopher Roche, -1

机译：C7β-甲基奥维诺尔的类似物：发现诺西汀/ orphanin FQ肽（NOP）制备阿片类阿片拮抗剂Mu阿片受体的受体局部激动和低或零功效。
7. Activation of Nociceptin Orphanin-FQ Peptide Receptors Disrupts Visual but not Auditory Sensorimotor Gating in BALB/cByJ Mice: Comparison to Dopamine Receptor Agonists [O] . Ces, Aurélia, Reiss, David, Walter, Ondine, 2011

机译：Nociceptin Orphanin-FQ肽受体的激活破坏了BALB / cByJ小鼠的视觉而不是听觉感觉门控：与多巴胺受体激动剂的比较

SAFETY, TOLERABILITY, AND EFFICACY OF A NOVEL, HIGHLY POTENT AND SELECTIVE PARTIAL AGONIST FOR NOCICEPTIN/ORPHANIN-FQ PEPTIDE (NOP) RECEPTORS IN PATIENTS WITH INSOMNIA DISORDER

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