The dual Inhibitor BEZ235 of the PI3K/mTor-Signaling Pathway enhances the Radiosensitivity of HNSCC-Cells by Inhibiting Double-strand Break Repair

Arenz A.; Balzer V; Dreffke K.; Wittig A.; Rieckmann T.; Koecher S.; Dikomey E.; U Schoetz; Engenhart-Cabillic R.

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The dual Inhibitor BEZ235 of the PI3K/mTor-Signaling Pathway enhances the Radiosensitivity of HNSCC-Cells by Inhibiting Double-strand Break Repair

机译：PI3K / MTOR-信号通路的双抑制剂BEZ235通过抑制双链断裂修复而增强了HNSCC细胞的放射敏感性

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《Strahlentherapie und Onkologie 》 |2018年第1期| 共2页
作者
Arenz A.; Balzer V; Dreffke K.; Wittig A.; Rieckmann T.; Koecher S.; Dikomey E.; U Schoetz; Engenhart-Cabillic R.;
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作者单位

Philipps Univ Marburg Klin Strahlentherapie &

Radioonkol Marburg Germany;

Philipps Univ Marburg Klin Strahlentherapie &

Radioonkol Marburg Germany;

Philipps Univ Marburg Klin Strahlentherapie &

Radioonkol Marburg Germany;

Univ Klinikum Jena Klin Strahlentherapie &

Radioonkol Jena Germany;

UKE Hamburg Lab Strahlenbiol &

Expt Radioonkol Hamburg Germany;

UKE Hamburg Lab Strahlenbiol &

Expt Radioonkol Hamburg Germany;

Philipps Univ Marburg Klin Strahlentherapie &

Radioonkol Marburg Germany;

Philipps Univ Marburg Klin Strahlentherapie &

Radioonkol Marburg Germany;

Philipps Univ Marburg Klin Strahlentherapie &

Radioonkol Marburg Germany;

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原文格式 PDF
正文语种 ger
中图分类放射医学 ;
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1. The dual Inhibitor BEZ235 of the PI3K/mTor-Signaling Pathway enhances the Radiosensitivity of HNSCC-Cells by Inhibiting Double-strand Break Repair [J] . Arenz A., Balzer V, Dreffke K., Strahlentherapie und Onkologie . 2018 ,第Suppla1期

机译：PI3K / MTOR-信号通路的双抑制剂BEZ235通过抑制双链断裂修复而增强了HNSCC细胞的放射敏感性
2. The PI3K/mTOR dual inhibitor BEZ235 nanoparticles improve radiosensitization of hepatoma cells through apoptosis and regulation DNA repair pathway [J] . Xiaolong Tang, Amin Li, Chunmei Xie, Nanoscale Research Letters . 2020 ,第1期

机译：PI3K / MTOR双抑制剂BEZ235纳米颗粒通过细胞凋亡和调节DNA修复途径改善肝癌细胞的放射敏化
3. PI3K/Akt/mTOR pathway inhibitors enhance radiosensitivity in radioresistant prostate cancer cells through inducing apoptosis, reducing autophagy, suppressing NHEJ and HR repair pathways [J] . L Chang, P H Graham, J Hao, Cell death & disease. . 2014 ,第10期

机译：PI3K / AKT / MTOR途径抑制剂通过诱导细胞凋亡，减少自噬，抑制NHEJ和HR修复途径，增强放射性前列腺癌细胞的放射敏感性
4. Repairing DNA double-strand breaks by the prokaryotic non-homologous end-joining pathway [C] . Nigel C. Brissett, Aidan J. Doherty Biochemical Society Symposium . 2009

机译：通过原核非同源终端连接途径修复DNA双链断裂
5. Clinical Pharmacokinetics of the Novel Combination of BEZ235, PI3K/mTOR Inhibitor, and Everolimus, mTOR Inhibitor: Phase I Clinical Studies and Non-Clinical Mechanistic Assessment [D] . Moorthy, Ganesh P. 2015

机译：BEZ235，PI3K / mTOR抑制剂和依维莫司，mTOR抑制剂的新型组合的临床药代动力学：I期临床研究和非临床机制评估
6. Dual PI3K/mTOR Inhibitor NVP-BEZ235 Enhances Radiosensitivity of Head and Neck Squamous Cell Carcinoma (HNSCC) Cell Lines Due to Suppressed Double-Strand Break (DSB) Repair by Non-Homologous End Joining [O] . Ulrike Schötz, Viola Balzer, Friedrich-Wilhelm Brandt, 2020

机译：PI3K / mTOR双重抑制剂NVP-BEZ235通过非同源末端连接抑制双链断裂（DSB）修复增强了头颈部鳞状细胞癌（HNSCC）细胞系的放射敏感性
7. The PI3K/mTOR dual inhibitor BEZ235 nanoparticles improve radiosensitization of hepatoma cells through apoptosis and regulation DNA repair pathway [O] . Xiaolong Tang, Amin Li, Chunmei Xie, 2020

机译：PI3K / MTOR双抑制剂BEZ235纳米颗粒通过细胞凋亡和调节DNA修复途径改善肝癌细胞的放射敏化

The dual Inhibitor BEZ235 of the PI3K/mTor-Signaling Pathway enhances the Radiosensitivity of HNSCC-Cells by Inhibiting Double-strand Break Repair

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