Assessment of the cytotoxic activity and the reduction power of Limoniastrum feei Girard (Batt.): a medicinal plant from Algerian Sahara: Medicinal plant as a source of bioactive compounds

摘要

This scientific work involves aphytochemical study of a medicinal plant endemic to the south of Algeria: Limoniatrum feei Girard (Batt.). The study of the antioxidant effects and the evaluation of the cytotoxicity were reported. Polar organic extracts: methanol, ethanol and acetone of L. feei presented considerable levels of phenols and flavonoids. These levels were ranged from 127.07 to 262.11 mg GAE/g and 84 to 157.88 mg CEQ/g, respectively. Considerable antioxidant activity of polar organic extracts of L. feei was revealed. In the DPPH scavenging method, methanolic extract expressed an IC_(50) of about 3.2 mug/mL which is comparable to that of the ascorbic acid (2.48 mug/mL). The same extract expressed strong antioxidant power against hydroxyl radical with an IC_(50) of about 36.33 mug/mL, which is higher than that of the ascorbic acid (61.83 mug/mL). In the test of the beta-carotene bleaching, acetone extract expressed a remarkable antioxidant power comparable to the positive control (IC_(50): 5.85 mug/mL and 4.26 mug/mL, respectively). A low cytotoxic activity against human red blood cells was exerced by the methanol extract of L. feei, this could explaine the safety uses of this plant by indigenous populations.