Intra-articular onabotulinumtoxinA in osteoarthritis knee pain: effect on human mechanistic pain biomarkers and clinical pain

Arendt-Nielsen L.; Jiang G-L; DeGryse R.; Turkel C. C.

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Intra-articular onabotulinumtoxinA in osteoarthritis knee pain: effect on human mechanistic pain biomarkers and clinical pain

机译：关节内的OnaboTulinumtoxina在骨关节炎膝关节疼痛：对人机疼痛生物标志物的影响和临床疼痛

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Objectives: OnabotulinumtoxinA (onabotA) attenuates peripheral nociceptive transduction and consequently neuronal firing. The aim of this mechanistic study was to evaluate the effect of intra-articular (IA) onabotA in patients with painful knee osteoarthritis (OA).

机译：目的：OnaboTulinumtoxina（Onabota）衰减外周伤害性转导，因此神经元烧制。该机制研究的目的是评估关节内（IA）Onabota在疼痛膝关节骨关节炎（OA）患者中的效果。

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《Scandinavian journal of rheumatology》 |2017年第4期|共14页
作者
Arendt-Nielsen L.; Jiang G-L; DeGryse R.; Turkel C. C.;
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作者单位

Aalborg Univ SMI Aalborg Denmark;

Sanofi Biosurg DPU Cambridge MA USA;

Allergan Pharmaceut Inc Irvine CA USA;

OticPharma Inc Irvine CA USA;

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原文格式 PDF
正文语种 eng
中图分类免疫性疾病;
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1. Intra-articular onabotulinumtoxinA in osteoarthritis knee pain: effect on human mechanistic pain biomarkers and clinical pain [J] . Arendt-Nielsen L., Jiang G-L, DeGryse R., Scandinavian journal of rheumatology . 2017,第4期

机译：关节内的OnaboTulinumtoxina在骨关节炎膝关节疼痛：对人机疼痛生物标志物的影响和临床疼痛
2. Relationships between biomarkers of cartilage, bone, synovial metabolism and knee pain provide insights into the origins of pain in early knee osteoarthritis [J] . Muneaki Ishijima, Taiji Watari, Kiyohito Naito, Arthritis Research . 2011,第1期

机译：软骨，骨骼，滑膜代谢和膝关节疼痛的生物标志物之间的关系为早期膝关节骨关节炎疼痛的起源提供了见识
3. Intra-articular platelet-rich plasma (PRP) injections for treating knee pain associated with osteoarthritis of the knee in the Japanese population: a phase I and IIa clinical trial [J] . Yu Taniguchi, Tomokazu Yoshioka, Akihiro Kanamori, Nagoya journal of medical science . 2018,第1期

机译：关节内富血小板血浆（PRP）注射治疗日本人群膝关节骨关节炎相关的膝关节疼痛：I和IIa期临床试验
4. Low Level Laser Therapy (LLLT) for Knee Osteoarthritis (OA) in NSAID Resistance Pain (Clinical Study on 386 Patients) [C] . S. Mokmeli, H. Attarian, M. Hosseini, International Congress of the World Association of Laser Therapy . 2006

机译：NSAID耐药疼痛膝关节骨关节炎（OA）低水平激光治疗（LLLT）（386例患者临床研究）
5. Gait mechanics, joint contact forces, and muscle forces in older adults with radiographic knee osteoarthritis and knee pain compared to a similar population with no radiographic knee osteoarthritis [D] . Wallace, Joshua F. 2014

机译：与没有影像学检查的膝关节骨关节炎的类似人群相比，患有影像学检查的膝关节骨关节炎和膝关节疼痛的老年人的步态力学，关节接触力和肌肉力
6. Relationships between biomarkers of cartilage bone synovial metabolism and knee pain provide insights into the origins of pain in early knee osteoarthritis [O] . Muneaki Ishijima, Taiji Watari, Kiyohito Naito, 2011

机译：软骨骨骼滑膜新陈代谢和膝关节疼痛的生物标志物之间的关系为早期膝关节骨关节炎疼痛的起源提供了见识
7. A single center, double-blind, randomized, placebo-controlled, parallel-group study of the efficacy and safety of intra-articular onabotulinumtoxina as treatment for osteoarthritis knee pain:results from the experimental pain models [O] . Arendt-Nielsen, Lars, Jiang, G.-L., DeGryse, R., 2014

机译：单中心，双盲，随机，安慰剂对照，平行组研究关节内onabotulinum toxina治疗骨关节炎膝关节疼痛的疗效和安全性：实验疼痛模型的结果

Intra-articular onabotulinumtoxinA in osteoarthritis knee pain: effect on human mechanistic pain biomarkers and clinical pain

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