Synthesis of Acyl Derivatives of Cotarnine

摘要

A. Cotarnine (1). A 250-mL, round-bottomed, three-necked flask is equipped with a magnetic stir bar (elliptical, 32 x 16 mm, Teflon-coated). The flask is dried under vacuum (1.8 mmHg) with a propane torch and then allowed to cool to 25 °C. The dried flask is then charged with nitric acid (150 mL, 18% (v/v) in H2O) and fitted with a reflux condenser complete with a nitrogen inlet, a thermometer, and the final neck is sealed with a rubber septum (Figure 1) (Notes 2, and 3).