SUZUKI-MIYAURA CROSS-COUPLING

摘要

In 1979, Akira Suzuki and Norio Miyaura introduced the coupling reaction of organoboron species and organo(pseudo)halides mediated by a palladium catalyst (Scheme 1). ,2 This reaction has evolved to become a very important method for carbon-carbon bond formation in organic chemistry. Suzuki-Miyaura is often the cross-coupling reaction of choice because it employs relatively non-toxic and stable organoboron species as the source of nucleophilic carbon (R2), proceeds under comparatively mild reaction conditions, displays extensive functional group compatibility, and generally affords high yields of cross-coupled product R1-R2.