TRANSITION-METAL-CATALYZED HYDROACYLATION

摘要

Transition-metal catalysis has revolutionized the way natural products and medicinal targets are made. For example, asymmetric hydrogenation, olefin metathesis, and cross-coupling have evolved into indispensable tools for drug discovery. As a complement to these well-established strategies, the metal-catalyzed activation of carbon-hydrogen bonds is an increasingly valuable and attractive approach. In metal-catalyzed hydroacylation, an aldehyde carbon-hydrogen bond is activated to generate either a carbon-carbon bond or carbon-oxygen bond, depending on the coupling partner used (e.g., alkene, alkyne, or carbonyl compound). This strategy represents an attractive, atom-economical approach for building both ketones and esters from aldehydes (Scheme 1).