Electrochemical Determination of Sertraline at Screen Printed Electrode Modified with Feather Like La3+/ZnO Nano-Flowers and Its Determination in Pharmaceutical and Biological Samples

摘要

In this paper, the use of a screen printed electrode modified by feather like La3+/ZnO nano-flowers for the determination of sertraline was described. These nano-flowers showed satisfactory catalytic activity for determination of sertraline by cyclic voltammetry (CV) and differential pulse voltammetry (DPV) methods. At the optimum pH of 7.0, the oxidation of sertraline occured at a potential about 280 mV less positive than that of an unmodified screen printed electrode. Based on DPV, the oxidation of sertraline exhibited a dynamic range between 0.5 and 150.0 mu M and a detection limit (3 sigma) of 0.15 +/- 0.01 mu M. The modified electrode had a good performance for sertraline detection in real samples by the standard addition method.