Regioselective C5 alkenylation of 2-acylpyrroles via Pd(II)-catalyzed C-H bond activation

摘要

A Pd(II)-catalyzed regioselective C5 alkenylation of 2-acylpyrroles has been developed employing 3-nitrile benzoyl group (N-(3-NCC6H4CO-)) as an efficient N-protecting group. The protocol provided a simple and efficient method to synthesize C5-alkenylated 2-acylpyrrole derivatives. The employed N-protecting group was readily removable in the presence of HCl/EtOH under mild conditions.