Topological Indices of Hyaluronic Acid-Paclitaxel Conjugates'Molecular Structure in Cancer Treatment

摘要

A large number of medical experiments have confirmed that the features of drugs have a close correlation with their molecular structure.Drug properties can be obtained by studying the molecular structure of corresponding drugs.The calculation of the topological index of a drug structure enables scientists to have a better understanding of the physical chemistry and biological characteristics of drugs.In this paper,we focus on Hyaluronic Acid-Paclitaxel conjugates which are widely used in the manufacture of anticancer drugs.Several topological indices are determined by virtue of the edge-partition method,and our results remedy the lack of medicine experiments,thus providing a theoretical basis for pharmaceutical engineering.