2 '-Hydroxyflavanone inhibits epithelial-mesenchymal transition, and cell migration and invasion via suppression of the Wnt/beta-catenin signaling pathway in prostate cancer

摘要

Despite the availability of a number of treatment options, certain cases of primary prostate cancer (PCa) will develop into metastatic PCa, in which epithelial-mesenchymal transition (EMT) serves an important role. Recently, a natural flavonoid known as 2'-hydroxyflavanone (2HF) exerts remarkable anticancer activity on various types of cancer. Our previous study demonstrated that 2HF could promote apoptosis and inhibit the proliferation of PCa cells, but whether 2HF is involved in the regulation of EMT, and cell migration and invasion in metastatic PCa remains unknown. The present study used two different metastatic PCa cell lines (PC-3 and DU145) to investigate the effects of 2HF on EMT, and cell migration and invasion. The results demonstrated that 2HF could inhibit EMT, and cell migration and invasion through the Wnt/beta-catenin signaling pathway by suppressing GSK-3 beta phosphorylation, beta P-catenin expression and transactivation. In conclusion, the present study revealed a novel function of 2HF, which may be used to prevent or treat PCa metastasis.