Effect of Early Tranexamic Acid Administration on Mortality, Hysterectomy, and Other Morbidities in Women With Post- Partum Haemorrhage (WOMAN): An International, Randomised, Double- blind, Placebo-Controlled Trial

摘要

Primary postpartum hemorrhage is responsible for approximately 100,000 deaths worldwide annually. Administration of tranexamic acid (TXA) to trauma patients within 3 hours of injury has been shown to reduce bleeding- related death by almost one third. This trial aimed to study the effects of early administration of TXA on adverse outcomes in women with postpartum hemorrhage.