Synthesis, spectral characterization, DNA interaction, antioxidant, and antimicrobial studies of new water soluble metal(II) complexes of morpholine based ligand

摘要

A new series of metal(II) complexes 1-5 of the type [M(L)(AcO)(2)H2O], where L is a bidentate ligand, 2-(3-morpholinopropylimino)methylphenol and M is Mn(II) (1), Co(II) (2), Ni(II) (3), Cu(II) (4), and Zn(II) (5), have been isolated and characterized by physico-chemical and spectral methods. Spectroscopic data supported the square pyramidal geometry around the central metal ion in the complexes 1-5. Absorption spectra and viscometric data indicated that the complexes 1-5 interacted with calf thymus (CT) DNA via intercalative strategy. Cleavage activities of complexes 1-5 with CT DNA were analyzed by gelelectrophoretic method. The in vitro antioxidant activity of complexes 1-5 was tested using the DPPH assay. The complexes 1-5 have been tested for antimicrobial activity against some pathogenic bacterial and fungal species by the agar well diffusion method.