The study of synergistic effects of ZnO decorated graphene nanosheets and room temperature ionic liquid for analysis of raloxifene in pharmaceutical samples

摘要

Raloxifene is an important estrogen receptor modulator with many side effects, and determination of this drug is very important in biological samples. The present research describes a ZnO decorated graphene nanosheet (ZnO/GrNS)/ionic liquid based electrochemical sensor for the measurement of raloxifene. The ZnO/GrNS were synthesized via direct chemical precipitation process and characterized using the SEM-EDAX technique. Due to excellent conductivity of ZnO/GrNS and ionic liquid, the suggested electrochemical sensor exhibited improved electrochemical response for raloxifene. After optimization of electrochemical conditions and at the best state, the fabricated electrode displayed two linear dynamic ranges (1.0 x 10(-10)-5.0 x 10(-6) and 1.0 x 10(-6)-5.0 x 10(-4) M) with a detection limit (DL) of 0.07 nM. Quantification analysis of raloxifene was successfully evaluated using the suggested sensor in pharmaceutical samples.