Comparison of linear intrascan and interscan dynamic ranges of Orbitrap and ion‐mobility time‐of‐flight mass spectrometers

Kaufmann Anton; Walker Stephan

摘要

Rationale >The linear intrascan and interscan dynamic ranges of mass spectrometers are important in metabolome and residue analysis. A large linear dynamic range is mandatory if both low‐ and high‐abundance ions have to be detected and quantitated in heavy matrix samples. These performance criteria, as provided by modern high‐resolution mass spectrometry (HRMS), were systematically investigated. </section> <section xml:id="rcm7981-sec-0002" numbered="no"> <title type="main">Methods >The comparison included two generations of Orbitraps, and an ion mobility quadrupole time‐of‐flight (QTOF) system In addition, different scan modes, as provided by the utilized instruments, were investigated. Calibration curves of different compounds covering a concentration range of five orders of magnitude were measured to evaluate the linear interscan dynamic range. The linear intrascan dynamic range and the resulting mass accuracy were evaluated by repeating these measurements in the presence of a very intense background. </section> <section xml:id="rcm7981-sec-0003" numbered="no"> <title type="main">Results >Modern HRMS instruments can show linear dynamic ranges of five orders of magnitude. Often, however, the linear dynamic range is limited by the detection capability (sensitivity and selectivity) and by the electrospray ionization. Orbitraps, as opposed to TOF instruments, show a reduced intrascan dynamic range. This is due to the limited C‐trap and Orbitrap capacity. The tested TOF instrument shows poorer mass accuracies than the Orbitraps. In contrast, hyphenation with an ion‐mobility device seems not to affect the linear dynamic range. </section> <section xml:id="rcm7981-sec-0004" numbered="no"> <title type="main">Conclusions >The linear dynamic range of modern HRMS instrumentation has been significantly improved. This also refers to the virtual absence of systematic mass shifts at high ion abundances. The intrascan dynamic range of the current Orbitrap technology may still be a limitation when analyzing complex matrix extracts. On the other hand, the linear dynamic range is not only limited by the detector technology, but can also be shortened by peripheral devices, where the ionization and transfer of ions take place. </section> </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract XMLNS =“http://www.wiley.com/namespaces/wiley”type =“main”xml：lang =“en”> <section xml：id =“rcm7981-sec-0001”编号=“否” > <标题类型=“main”>基本原理</ title> >质谱仪的线性Intascan和Interscan动态范围在代谢物和残留分析中是重要的。如果必须在重型基质样品中检测到和定量低高度离子和定量，则强制性的线性动态范围是强制性的。这些性能标准，如现代高分辨率质谱（HRMS）所提供的系统地研究。</ p> </ section> <secto XML：ID =“RCM7981-SEC-0002”编号为“否”> <标题类型=“main”>方法</ title> >比较包括两代露天的露天时间（以及离子移动性四极针飞行时间（qtof）系统，除了使用仪器提供的不同的扫描模式，被调查了。测量覆盖浓度范围的不同化合物的校准曲线，以评估线性间隙动态范围。通过在存在非常激烈的背景下重复这些测量来评估线性体内体动态范围和所得到的质量准确度。</ p> </ section> <section XML：ID =“RCM7981-SEC-0003”编号=“NO “> <标题类型=”main“>结果</ title> >现代HRMS仪器可以显示五个数量级的线性动态范围。然而，通常，线性动态范围受到检测能力（灵敏度和选择性）和电喷雾电离的限制。与TOF仪器相反，露天表现出了减少的体系动态范围。这是由于C-Trap和绕组能力有限。经过测试的TOF仪器表现出比露珠的质量较差。相反，具有离子移动装置的连字似乎不会影响线性动态范围。</ p> </ section> <section xml：id =“rcm7981-sec-0004”编号=“否”> <标题类型= “主要”>结论</标题> >现代HRMS仪器的线性动态范围显着提高。这也是指高离子丰富的虚拟缺失。当分析复杂的基质提取物时，目前轨道技术的Intrascan动态范围仍可能是一个限制。另一方面，线性动态范围不仅受到探测器技术的限制，而且还可以由外围设备缩短，其中离子化和离子的转移发生。</ p> </段> </摘要> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-26627/'>《Rapid Communications in Mass Spectrometry: RCM》</a> <b style="margin: 0 2px;">|</b><span>2017年第22期</span><b style="margin: 0 2px;">|</b><span>共12页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Kaufmann Anton&option=202" target="_blank" rel="nofollow">Kaufmann Anton;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Walker Stephan&option=202" target="_blank" rel="nofollow">Walker Stephan;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Official Food Control AuthorityFehrenstrasse 15 8032 Zürich Switzerland;</p> <p>Official Food Control AuthorityFehrenstrasse 15 8032 Zürich Switzerland;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/1187.html" title="分析化学">分析化学;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> </p> </li> </ul> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul> <li class="active" >外文文献</li> <li >中文文献</li> <li >专利</li> </ul> </div> <div class="similarity_details"> <ul > <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704024020346.html">Comparison of linear intrascan and interscan dynamic ranges of Orbitrap and ion‐mobility time‐of‐flight mass spectrometers</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Kaufmann Anton&option=202" 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href="/patent-detail/06120110468865.html">动态扫描的宽质量范围飞行时间质谱仪及检测方法</a> <b>[P]</b> . <span> 中国专利： CN107978508A </span> <span> . 2018-05-01</span> </div> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/patent-detail/06120207867319.html">动态扫描的宽质量范围飞行时间质谱仪</a> <b>[P]</b> . <span> 中国专利： CN207868163U </span> <span> . 2018-09-14</span> </div> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/patent-detail/06130449754213.html">Ion source and accelerator for improved dynamic range and mass selection in a time of flight mass spectrometer</a> <b>[P]</b> . <span> 外国专利：  US6080985A </span> <span> . 2000-06-27</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：离子源和加速器，可改善飞行时间质谱仪的动态范围和质量选择 </span> </p> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/patent-detail/06130452163640.html">Ion source and accelerator for improved dynamic range and mass selection in a time of flight mass spectrometer</a> <b>[P]</b> . <span> 外国专利：  EP0905743A1 </span> <span> . 1999-03-31</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：离子源和加速器，可改善飞行时间质谱仪的动态范围和质量选择 </span> </p> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/patent-detail/06130413966512.html">Method for acquiring mass spectrometric data from ion and ion mobility time of flight mass spectrometer system</a> <b>[P]</b> . <span> 外国专利：  DE102012220552B4 </span> <span> . 2015-02-12</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：从离子和飞行时间质谱仪系统的离子迁移时间获取质谱数据的方法 </span> </p> </li> </ul> </div> </div> </div> <div class="theme cardcommon" style="overflow: auto;display:none"> <h3 class="all_title" 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