Nitrogen direct analysis in real time time-of-flight mass spectrometry (N-2 DART-TOFMS) for rapid screening of forensic drugs

摘要

Rationale Over the last ten years, helium direct analysis in real time time-of-flight mass spectrometry (He DART-TOFMS) has become an established technique in rapid screening of forensic drugs to decrease the time necessary to triage forensic drug cases, therefore contributing to backlog reduction and more timely criminal prosecution. Recently, we demonstrated that N-2 DART was able to efficiently ionize all polar compounds except for a few extremely small ones such as methanol and acetonitrile. Therefore, N-2 DART-TOFMS should be a suitable technique for rapid screening of forensic drugs.