Synthesis of 1,2-Diarylethylenes by Pd-Catalyzed One-Pot Reaction of Benzyl Halides, Tosylhydrazide, and Aryl Aldehydes

摘要

Background: Substituted olefins are versatile functional groups and intermediates in chemistry,medicine, electronics, and optics and materials science fields because of their unique properties.One important class of substituted olefins 1,2-diarylethylenes have attracted considerable attention dueto their presence in both natural products and pharmacologically active substances.Methods: In this paper, we developed a one-pot two-step coupling reaction of aryl aldehydes, tosylhydrazidewith benzyl halides by using inexpensive Pd(PPh3)4 as catalyst, leading to a variety of 1,2-diphenylethenes derivatives with moderate to good yields.Results: The desired 1,2-diarylethylenes were obtained in 46-96% yields via Pd(0)-catalyzed one-potreaction of benzyl halides, tosylhydrazide, and aryl aldehydes.Conclusion: The catalytic system presented here enables the use of easily accessible starting materialsand good functional group tolerance.