首页> 外文期刊>Neurobiology of Aging: Experimental and Clinical Research >Anticholinergic drug use is associated with episodic memory decline in older adults without dementia
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Anticholinergic drug use is associated with episodic memory decline in older adults without dementia

机译:抗胆碱能药物使用与没有痴呆的老年人的情节记忆下降有关

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Anticholinergic drug use is common in older adults and has been related to increased dementia risk. This suggests that users of these drugs may experience accelerated cognitive decline. So far, however, longitudinal data on this topic are absent and the available evidence is inconclusive with respect to effects on specific cognitive domains due to suboptimal control of confounding variables. We investigated whether anticholinergic medication use is associated with cognitive decline over 6 years in a population-based study of older adults (aged 60-90; n = 1473) without dementia. We found that users (n = 29) declined more on episodic memory over 6 years compared to nonusers (n = 1418). These results were independent of age, sex, education, overall drug intake, physical activity, depression, cardiovascular risk burden, and cardiovascular disease. By contrast, anticholinergic drug use was unrelated to performance in processing speed, semantic memory, short-term memory, verbal fluency, and global cognition (the Mini-Mental-State Examination). Our results suggest that effects of anticholinergics may be particularly detrimental to episodic memory in older adults, which supports the assertion that the cholinergic system plays an important role in episodic memory formation. (C) 2017 Elsevier Inc. All rights reserved.
机译:抗胆碱能药物在老年人中是常见的,与痴呆症的风险增加有关。这表明这些药物的用户可能会经历加速的认知下降。然而,到目前为止,关于该主题的纵向数据不存在,并且可用的证据是由于对混淆变量的次优控制的特异性认知结构域的影响而不确定。我们研究了抗胆碱能药物药物治疗是否与在没有痴呆的基于群体的人口(年龄60-90; n = 1473)的基于人群的血液研究中有关的认知下降。我们发现,与非用户相比,用户(n = 29)在6年内逐渐下降6年(n = 1418)。这些结果与年龄,性别,教育,整体药物摄入,身体活动,抑郁,心血管危险负担和心血管疾病无关。相比之下,抗胆碱能药物使用与加工速度,语义记忆,短期记忆,口头流畅性和全球认知(迷你态度考试)无关。我们的研究结果表明,抗胆碱能器的影响可能对老年人的嗜血态尤为有害,这支持胆碱能系统在脑内记忆形成中起重要作用的断言。 (c)2017年Elsevier Inc.保留所有权利。

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