Pilot study of Biomarkers for predicting effectiveness of ramosetron in diarrhea-predominant irritable bowel syndrome: expression of S100A10 and polymorphisms of TPH1

Shiotani A.; Kusunoki H.; Ishii M.; Imamura H.; Manabe N.; Kamada T.; Hata J.; Merchant J. L.; Haruma K.

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Pilot study of Biomarkers for predicting effectiveness of ramosetron in diarrhea-predominant irritable bowel syndrome: expression of S100A10 and polymorphisms of TPH1

机译：用于预测腹泻急性肠辨别综合征的ramosetron效果的生物标志物的试验研究：S100A10的表达及TPH1的多态性

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BackgroundSerotonin type 3 receptor (5-HT3R) antagonists are potentially useful therapeutic agents for diarrhea-predominant irritable bowel syndrome (IBS-D). To identify biomarkers predicting effectiveness of the 5-HT3R antagonist (ramosetron) in IBS-D.

机译：Backgroundserotonin Type 3受体（5-HT3R）拮抗剂是腹泻的潜在有用的治疗剂，用于腹泻 - 主要肠易激综合征（IBS-D）。确定预测IBS-D中5-HT3R拮抗剂（Ramosetron）的有效性的生物标志物。

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来源
《Neurogastroenterology and motility》 |2015年第1期|共10页
作者
Shiotani A.; Kusunoki H.; Ishii M.; Imamura H.; Manabe N.; Kamada T.; Hata J.; Merchant J. L.; Haruma K.;
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作者单位

Kawasaki Med Univ Dept Internal Med Kurashiki Okayama 7010192 Japan;

Kawasaki Med Univ Dept Comprehens Med Kurashiki Okayama 7010192 Japan;

Kawasaki Med Univ Dept Internal Med Kurashiki Okayama 7010192 Japan;

Kawasaki Med Univ Dept Clin Pathol &

Lab Med Kurashiki Okayama 7010192 Japan;

Kawasaki Med Univ Dept Clin Pathol &

Lab Med Kurashiki Okayama 7010192 Japan;

Kawasaki Med Univ Dept Internal Med Kurashiki Okayama 7010192 Japan;

Kawasaki Med Univ Dept Clin Pathol &

Lab Med Kurashiki Okayama 7010192 Japan;

Univ Michigan Dept Internal Med &

Mol &

Integrat Physiol Ann Arbor MI 48109 USA;

Kawasaki Med Univ Dept Internal Med Kurashiki Okayama 7010192 Japan;

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原文格式 PDF
正文语种 eng
中图分类消化系及腹部疾病;
关键词
resistance; serotonin type 3 receptor antagonists; TPH1 rs211105;

机译：抗性;血清素3型受体拮抗剂;TPH1 RS211105;

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专利

1. Pilot study of Biomarkers for predicting effectiveness of ramosetron in diarrhea-predominant irritable bowel syndrome: expression of S100A10 and polymorphisms of TPH1 [J] . Shiotani A., Kusunoki H., Ishii M., Neurogastroenterology and motility . 2015,第1期

机译：生物标志物预测雷莫司琼在腹泻型肠易激综合征中的有效性的初步研究：S100A10的表达和TPH1的多态性
2. The TPH1 rs211105 gene polymorphism affects abdominal symptoms and quality of life of diarrhea-predominant irritable bowel syndrome [J] . Ryo Katsumata, Akiko Shiotani, Takahisa Murao, Journal of clinical biochemistry and nutrition. . 2018,第3期

机译：TPH1 rs211105基因多态性影响腹泻型肠易激综合征的腹部症状和生活质量
3. Efficacy of serotonin type 3 receptor antagonist ramosetron in the treatment of diarrhea-predominant irritable bowel syndrome with inactive Crohn's disease, a pilot trial [J] . Nakamura K., Tomita T., Oshima T., Neurogastroenterology and motility . 2014,第Suppla1期

机译：血清素3型受体拮抗剂雷莫司琼治疗腹泻型肠易激综合症合并非活动性克罗恩病的疗效，一项先导试验
4. The Effects of Wumei Pill on Intestinal Flora and Neurotransmitters in Rats with Diarrhea-predominant Irritable Bowel Syndrome (IBS-D) [C] . Xiaojie Ding, Xiling Sun, Xiaofei Yu, International Conference on Biotechnology and Bioengineering . 2019

机译：尿布丸对腹泻的肠道菌群和神经递质的影响（IBS-D）
5. A Mixed Methods Study of Cognitive Flexibility in Irritable Bowel Syndrome [D] . Bedell, Alyse. 2019

机译：一种混合方法在肠易激综合征中的认知灵活性研究
6. Pilot study of Biomarkers for predicting effectiveness of ramosetron in diarrhea-predominant irritable bowel syndrome: expression of S100A10 and polymorphisms of TPH1 [O] . Akiko Shiotani, Hiroaki Kusunoki, Mnabu Ishii, -1

机译：生物标记物用于预测雷莫司琼在腹泻型肠易激综合征中的有效性的初步研究：S100A10的表达和TPH1的多态性
7. Pilot study of Biomarkers for predicting effectiveness of ramosetron in diarrhea‐predominant irritable bowel syndrome: expression of S100A10 and polymorphisms of TPH [O] . Shiotani, A., Kusunoki, H., Ishii, M., 2015

机译：生物标志物用于预测雷莫司琼在腹泻型肠易激综合征中的有效性的初步研究：s100a10的表达和TpH的多态性

Pilot study of Biomarkers for predicting effectiveness of ramosetron in diarrhea-predominant irritable bowel syndrome: expression of S100A10 and polymorphisms of TPH1

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