A Nationwide Epidemiological Study of Calf Spleen Extractive Injection (CSEI) Use in the Chinese Population: Direction for Biochemical Drugs

摘要

Understanding the effects and safety of biochemical drugs is important during clinical practice. The purpose of this epidemiological study is to describe the relationship between the clinical outcomes of calf spleen extractive injection (CSEI), a representative biochemical drug. In the retrospective and cross-sectional study, 5163 cancer patients who had undergone chemotherapy were randomly selected from hospitals in 18 different provinces in China and interviewed face-to-face using a structured questionnaire. Association analyses were conducted to examine correlates between CSEI use and clinical variables, clinical outcomes, and possible side-effects. In the survey, 93.0% of the patients obtained improved clinical outcomes, suggesting that CSEI is an effective agent for the adjuvant treatment of cancer. Side-effects after CSEI use were associated with being aged between 18 and 45 years (odds ratio [OR], 2.573; 95% confidence interval [CI], 2.027 to 3.267; p < 0.001), single/divorced/widowed status (OR, 2.432; 95% CI, 1.920 to 3.081; p< 0.001), and low household income (OR, 2.418; 95% CI, 1.393 to 4.195; p = 0.002). Of the 20 side-effects listed in our questionnaire, dizziness was most common, accounting for 60.2% of all terms. Our study shows that the use of CSEI is a good choice for cancer patients undergoing chemotherapy, and provides useful hints for the clinical application of biochemical drugs in general, not only CESI.