Functionalized beta-Cyclodextrin Immobilized on Ag-Embedded Silica Nanoparticles as a Drug Carrier

摘要

Cyclodextrins (CDs) have beneficial characteristics for drug delivery, including hydrophobic interior surfaces. Nanocarriers with beta-CD ligands have been prepared with simple surface modifications as drug delivery vehicles. In this study, we synthesized beta-CD derivatives on an Ag-embedded silica nanoparticle (NP) (SiO2@Ag NP) structure to load and release doxorubicin (DOX). Cysteinyl-beta-CD and ethylenediamine-beta-CD (EDA-beta-CD) were immobilized on the surface of SiO2@Ag NPs, as confirmed by transmission electron microscopy (TEM), ultraviolet-visible (UV-Vis) spectrophotometry, and Fourier transform infrared (FTIR) spectroscopy. DOX was introduced into the beta-CD on the SiO2@Ag NPs and then successfully released. Neither cysteinyl-beta-CD and EDA-beta-CD showed cytotoxicity, while DOX-loaded cysteinyl-beta-CD and EDA-beta-CD showed a significant decrease in cell viability in cancer cells. The SiO2@Ag NPs with beta-CD provide a strategy for designing a nanocarrier that can deliver a drug with controlled release from modified chemical types.