Results of a Phase II Placebo-controlled Randomized Discontinuation Trial of Cabozantinib in Patients with Non-small-cell Lung Carcinoma

摘要

Cabozantinib is an inhibitor of receptor tyrosine kinases, including MET, vascular endothelial growth factor receptors, AXL, RET, and ROS1. We assessed cabozantinib in 60 patients with non small-cell lung carcinoma enrolled in a phase II randomized discontinuation trial. Tumor regression was observed in most patients, including patients with KRAS and epidermal growth factor receptor mutations. The safety profile was consistent with that reported for cabozantinib in other solid tumors.