Microwave-Assisted Dehydrogenative Cross Coupling Reactions in -valerolactone with a Reusable Pd/-cyclodextrin Crosslinked Catalyst

摘要

Transition-metal mediated C-H bond activation and functionalization is one of the most straightforward and powerful tools in modern organic synthetic chemistry. Oxidative C-H/C-H coupling reactions between two (hetero)arenes under heterogeneous catalysis may be a valuable means for the production of a plethora of bi(hetero)aryls, and one that adheres to the increasing demand for atom-economic and sustainable chemistry. We have therefore developed a reusable heterogeneous catalytic system, which is based on Pd cross-linked -cyclodextrin, to perform an efficient microwave-assisted oxidative C-H/C-H cross coupling process between benzothiazoles and methyl thiophene in the presence of green solvents.