首页> 外文期刊>Molecular and Cellular Endocrinology >Administration of eicosapentaenoic and docosahexaenoic acids may improve the remodeling and browning in subcutaneous white adipose tissue and thermogenic markers in brown adipose tissue in mice
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Administration of eicosapentaenoic and docosahexaenoic acids may improve the remodeling and browning in subcutaneous white adipose tissue and thermogenic markers in brown adipose tissue in mice

机译:eicosapentaenoic和二十二磺酰己烯酸的施用可以改善皮下白色脂肪组织和小鼠棕色脂肪组织中的热原标记的重塑和褐变

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摘要

The role of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in browning and thermogenesis has not been fully elucidated. Thus, we meant to evaluate the effect of EPA and DHA, administered alone or combined, with the activation of browning markers in subcutaneous white adipose tissue (sWAT), and thermogenic markers in brown adipose tissue (BAT). C57BL/6 adult male mice received a control diet or a high-fructose diet (HFru) for eight weeks, but after the first three weeks, HFru was divided into new groups: HFru, HFru + EPA, HFru + DHA, and HFru-EPA + DHA. EPA and DHA diminished adipocyte hypertrophy, recovered markers of browning in sWAT and thermogenic factors in the BAT, and improved gene expressions linked with mitochondrial biogenesis and lipid metabolism. Importantly, EPA and DHA administrated alone showed stronger results than the combination of EPA + DHA. The results suggest that EPA and DHA might be useful as adjuvant strategies to treat metabolic-associated disorders.
机译:赤素辛化苯甲酸(EPA)和十二碳六烯酸(DHA)在褐变和热生成中的作用尚未完全阐明。 因此,我们的意思是评估EPA和DHA的效果,单独给药或组合,并在皮下白色脂肪组织(SWAT)中的褐变标志物激活,以及棕色脂肪组织(BAT)中的热标志物。 C57BL / 6成年男鼠接受了控制饮食或高果糖饮食(HFRU)八周,但在前三周后,HFRU分为新的群体:HFRU,HFRU + EPA,HFRU + DHA和HFRU- EPA + DHA。 EPA和DHA减少了脂肪细胞肥大,在SWAT和蝙蝠中的热因子中恢复的褐变标记,以及与线粒体生物发生和脂质代谢相关的改进的基因表达。 重要的是,EPA和DHA单独展示比EPA + DHA的组合更强。 结果表明,EPA和DHA可能是治疗代谢相关疾病的辅助策略。

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