首页> 外文期刊>Mechanics research communications >A biomechanical simulation of the brain glioma growth considering the effects of oxygen Bunsen solubility coefficient
【24h】

A biomechanical simulation of the brain glioma growth considering the effects of oxygen Bunsen solubility coefficient

机译:考虑到氧气囊升溶解度系数的影响的脑胶质瘤生长的生物力学模拟

获取原文
获取原文并翻译 | 示例
           

摘要

Oxygen plays a critical role in human cell survival and proliferation; hence, it is an essential factor in cancer tumor propagation. In the literature, many studies have investigated the oxygen contribution to cell proliferation and tumor growth; however, lack of the studies considering the effect of blood oxygen solubility on the tumor growth is remarkably sensed among the literature. Accordingly, in this study, we investigated the effect of oxygen Bunsen solubility coefficient on the brain glioma growth, following continuum mechanics principles. A biomechanical simulation was conducted by assuming a compressible hyperelastic model of growth for spherical glioma tissue. Patient-specific MRI dataset was utilized to develop the geometry of the brain. An isotropic growth deformation tensor alongside oxygen and cell number concentration relations were applied to the simulation. The results demonstrated that the tumor maximum volume at the end of 90 days decreased from 1315.59 mm(3) to 1236.43 mm(3), as the increase of oxygen Bunsen solubility coefficient for 20 %. Thus, we concluded that the accessibility of oxygen with higher values of blood solubility lowers the risk of tumor sudden growth, which was verified in comparison to literature experiments. (C) 2020 Elsevier Ltd. All rights reserved.
机译:氧在人体细胞存活和增殖中起着关键作用;因此,它是癌症肿瘤繁殖的重要因素。在文献中,许多研究研究了对细胞增殖和肿瘤生长的氧贡献;然而,在文献中,考虑到缺乏血氧溶解度对肿瘤生长的影响的研究非常感测。因此,在这项研究中,在连续的力学原理之后,研究了氧气Bunsen溶解度系数对脑胶质瘤生长的影响。通过假设球形胶质瘤组织的可压缩超弹性模型来进行生物力学模拟。使用患者特定的MRI数据集来开发大脑的几何形状。伴随着氧气和细胞数浓度关系的各向同性生长变形张量被应用于模拟。结果表明,90天末端的肿瘤最大体积从1315.59mm(3)〜1236.43mm(3)减少,因为氧气囊烯溶解度系数的增加20%。因此,我们得出结论,血液溶解度较高的氧气可达性降低了肿瘤突然生长的风险,与文献实验相比验证。 (c)2020 elestvier有限公司保留所有权利。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号