One-pot green synthesis of reduced graphene oxide decorated with beta-Ni (OH)(2)-nanoflakes as an efficient electrochemical platform for the determination of antipsychotic drug sulpiride

摘要

A promising electrochemical platform was fabricated for the quantification of a typical antipsychotic drug, sulpiride (SUL), in different human fluids. The proposed electrochemical sensor was fabricated using beta-Ni(OH)(2), reduced graphene oxide (Gr) and ionic liquid (IL). The designed sensor (Ni(OH)(2)center dot Gr-IL/CPE) integrates the features of nanostructured beta-Ni(OH)(2), Gr, and IL to achieve a high response and best sensitivity. Square wave voltammetry (SWV) was used for the detection of SUL in different complex matrices, while different techniques were utilized to characterize the proposed sensor features. Applying the optimal conditions, the developed platform exhibited a wide linear range 1.0 x 10(-9) to 2.0 x 10(-4) mol L-1 with a calculated limit of detection 2.50 x 10(-10) mol L-1. Furthermore, the designed sensor displayed good stability, selectivity and reproducibility, allowing the quantitative analysis of SUL in pharmaceutical preparation, human plasma and urine. The established electrochemical sensor is a potential prototype that can be applied in quality control work in the pharmaceutical industry.