New universal primers for genotyping and resistance detection of low HBV DNA levels

Tong Yongqing; Liu Bei; Liu Hui; Zheng Hongyun; Gu Jian; Liu Hang; Lin Min; Ding Yali; Song Chunhua; Li Yan

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New universal primers for genotyping and resistance detection of low HBV DNA levels

机译：用于低HBV DNA水平的基因分型和电阻检测的新普遍引物

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摘要

HBV (hepatitis B virus) genotyping is important in determining the clinical manifestation of disease and treatment response, particularly, in patients with low viral loads. Also, sensitive detection of HBV antiviral drug resistance mutations is essential for monitoring therapy response.

机译：HBV（乙型肝炎病毒）基因分型对于确定疾病和治疗反应的临床表现，特别是在病毒载量低的患者中是重要的。此外，HBV抗病毒耐药性突变的敏感性检测对于监测治疗反应是必不可少的。

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来源
《Medicine.》 |2016年第33期|共7页
作者
Tong Yongqing; Liu Bei; Liu Hui; Zheng Hongyun; Gu Jian; Liu Hang; Lin Min; Ding Yali; Song Chunhua; Li Yan;
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作者单位

Wuhan Univ Renmin Hosp Dept Clin Lab 99 Ziyang Rd Wuchang Dist Wuhan 430060 Peoples R China;

Wuhan Univ Sci &

Technol Tianyou Hosp Dept Pathol Wuhan Peoples R China;

Second Mil Med Univ Eastern Hepatobiliary Surg Hosp Shanghai Peoples R China;

Wuhan Univ Renmin Hosp Clin Mol Diagnost Ctr Wuhan Peoples R China;

Wuhan Univ Renmin Hosp Dept Clin Lab 99 Ziyang Rd Wuchang Dist Wuhan 430060 Peoples R China;

Wuhan Univ Renmin Hosp Clin Mol Diagnost Ctr Wuhan Peoples R China;

Penn State Univ Coll Med Hershey PA USA;

Penn State Univ Coll Med Hershey PA USA;

Penn State Univ Coll Med Hershey PA USA;

Wuhan Univ Renmin Hosp Dept Clin Lab 99 Ziyang Rd Wuchang Dist Wuhan 430060 Peoples R China;

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原文格式 PDF
正文语种 eng
中图分类医药、卫生;
关键词
genotyping; HBV; low DNA; resistance mutation;

机译：基因分型;HBV;低DNA;抗性突变;

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专利

1. New universal primers for genotyping and resistance detection of low HBV DNA levels [J] . Tong Yongqing, Liu Bei, Liu Hui, Medicine. . 2016,第33期

机译：新型通用引物，用于低HBV DNA水平的基因分型和耐药性检测
2. Higher detection rates of amino acid substitutions in HBV reverse transcriptase/surface protein overlapping sequence is correlated with lower serum HBV DNA and HBsAg levels in HBeAg-positive chronic hepatitis B patients with subgenotype B2 [J] . Su Mingze, Xiang Kuanhui, Li Yao, Infection, Genetics and Evolution: Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases . 2016,第Null期

机译：在HBeAg阳性的慢性乙型肝炎乙型肝炎患者中，HBV逆转录酶/表面蛋白重叠序列中氨基酸取代的较高检测率与较低的血清HBV DNA和HBsAg水平相关
3. Impact of HBV HBV genotype and mutations on HBV DNA HBV DNA and qHBsA qHBsA g levels in patients with HB HB eAg‐negative chronic HBV HBV infection [J] . Kuhnhenn L., Jiang B., Kubesch A., Alimentary pharmacology & therapeutics. . 2018,第11期

机译：HBV DNA HBV DNA和QHBSA QHBSA G水平患者HBV DNA HBV基因型及突变对HB HB eg阴性慢性HBV感染的影响
4. Noninvasive Detection of Response and Resistance in EGFR-Mutant Lung Cancer Using Quantitative Next-Generation Genotyping of Cell-Free Plasma DNA [C] . Cloud P. Paweletz, Geoffrey R. Oxnard, Yanan Kuang, Molecular Medicine TRI-CON. . 2014

机译：无细胞血浆DNA定量下一代基因分型非富集突变体肺癌响应和抗性的非侵袭性检测
5. Relations of bone mineral density, blood lead levels, bone lead levels and the apolipoprotein E and vitamin D receptor genotypes [D] . Theppeang, Keson 2008

机译：骨矿物质密度，血铅水平，骨铅水平与载脂蛋白E和维生素D受体基因型的关系
6. New universal primers for genotyping and resistance detection of low HBV DNA levels [O] . Yongqing Tong, Bei Liu, Hui Liu, -1

机译：新型通用引物用于低HBV DNA水平的基因分型和耐药性检测
7. New universal primers for genotyping and resistance detection of low HBV DNA levels [O] . Yongqing Tong, Bei Liu, Hui Liu, 2016

机译：低HBV DNA水平的基因分型和电阻检测的新普遍引物
8. Quantitative Analysis of Low Levels of Benzo(A)Pyrene Diol Epoxide Bound to DNA: Acid-Induced Liberation of Tetraols Followed by HPLC and Fluorometric Detection [R] . Rahn, R. O., Holland, J. M., Shugart, L. R. 1982

机译：定量分析低水平的苯并（a）芘二醇环氧化物与DNa结合：酸诱导的四醇溶解随后HpLC和荧光检测

New universal primers for genotyping and resistance detection of low HBV DNA levels

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